| Effect of Indomethacin Therapy in Prematurity with Patent Ductus Arteriosus:study of Its Effectiveness in Treatment Modality |
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Yun Kyeong Bae, Seong Woo Roh, Min Jeong Kim, Son Sang Seo |
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Department of Pediatrics, Il Sin Christian Hospital, Pusan, Korea |
| 미숙아 동맥관개존증에서 인도메타신의 치료효과: 투여방법에 따른 결과 비교 |
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배윤경, 노성우, 김민정, 서손상 |
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일신 기독병원 소아과 |
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| Abstract |
Purpose
: Conventional indomethacin therapy(0.2mg/kg every 12 hours for three doses) has been
used for closure of PDA. The effect of prolonged low dose of indomethacin therapy(0.1mg/kg
daily for six days)had been reported in foreign country but, nothing had been reported in our
country. So we attempted this study to examine effects of these two methods.
Methods
: Forty one infants with PDA of prematurity from January 1992 to July 1995 who
were admitted in NICU of Il Sin Christian Hospital were included. 27 of these infants received
conventional dose of indomethacin therapy and 14 received prolonged low dose of indomethacin
therapy, and we examined with closure rate and complication etc.
Results
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1) Closure of PDA was observed in 15(55.6%) and relapse was 3(11.1%) in conventional dose
therapy group. In prolonged low dose therapy group, closure was 8(57.1%) and relapse was none.
2) Intraventricular hemorrhage was observed in 20(74.1%), 6(42.9%) and gastrointestinal tract
bleeding was 6(22.2%), 13(92.2%) in each group. There was statistically significant between the
two groups(p<0.05).
3) The rise of serum BUN, creatinine was observed in 9(33.3%), 6(46.2%), bleeding tendency
was 9(33.3%), 8(57.1%), necrotizing enterocolitis was 2(7.4%), 0 and retinopathy of prematurity
was 8(29.6%), 3(21.4%) in each group.But there was not statistically significant correlation
between the two groups.
4) The development of sepsis and broncopulmonary dysplasia was slightly more in prolonged
low dose therapy group.
5) The reduction of urine output was observed in 11(40.7%), 2(14.3%) in each group but,
absolute oliguria was not observed in both groups.
Conclusion
: Though the closure rate of PDA was similar in both groups, prolonged low dose
indomethacin therapy can be recommanded with its effectiveness on preventing the relapse of
PDA and the accurrence of necrotizing enterocolitis. |
| Key Words:
PDA, prematurity, indomethacin, treatment modality |
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