| Relation of Umbilical Cord Blood Insulin/C-peptide to Neonatal Anthropometric Measures in Offspring of Mother with Normal Glucose Metabolism |
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Sun Young Kho1, Hye Kyung Han1, Mi Ryung Uhm1, Kyung Hoon Kim1, Mi Na Lee1, Hak Chul Jang2, Moon-young Kim3 |
1Departments of Pediatrics, Cheil General Hospital, Seoul, Korea
2Departments of Internal Medical, Cheil General Hospital, Seoul, Korea
3Departments of Obstetrics & Gynecology, Cheil General Hospital, Seoul, Korea |
| 정상 혈당 산모에서 출생한 신생아의 제대혈 인슐린 및 C-peptide농도와 신체 계측치와의 상관 관계 |
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고선영1, 한혜경1, 엄미령1, 최경훈1, 이미나1, 장학철2, 김문영3 |
1제일병원 소아과
2제일병원 내과
3제일병원 산부인과 |
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| Abstract |
Purpose
: We tried to find the relationships between the fetal beta-cell function and neonatal
birth weight, anthropometric measures, and maternal characteristics, and to observe role of
insulin as fetal growth factor in offsprings of mothers who have normal glucose metabolism.
Methods
: We measured umbilical cord blood insulin and C-peptide concentrations in 236
neonates delivered at Cheil General Hospital from Jan. 1 to Jan. 31 1994. Their mothers had
normal glucose metabolism during pregnancy. The birth weight and other anthropometric
measures were performed within 24 hours after birth by same pediatrician.
Results
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1) The mean gestational age was 39.5¡¾-0.1 wk and mean birth weight was 3.3¡¾-0.2 Kg.
According to birth weight percentile, the numbers of small for gestational age(SGA), adequete
for gesational(AGA), and large for gestational age(LGA) infans were 3(1.3%), 178(75.4%), and
55(23.3%), respectively. There were no differences in gestational age, birth weight, length, head
circumference, chest circumference, Ponderal index, and symmerty index between male and
female infants.
2) The maternal weight gain during pregnancy was related to neonatal birth weight, length,
and head circumference, but not to Ponderal index and symmetry index.
3) The mean cord blood insulin and C-peptide concentrations were 5.1¡¾-0.1uU/ml and
1.3¡¾-0.1 ng/ml. There was a significant positive correlation between insulin and C-peptide
concentrations.
4) There were no significant differences in cord blood insulin and C-peptide concentrations
among the SGA, AGA, and LGA group.
5) The cord blood insulin and C-peptide concentrations had weak positive correlations with
neonatal birth weight, obesity, and gestational age, but nor with maternal weight gain during
pregnancy.
Conclusion
: Although insulin has a significant role in fetal growth in diabetic pregnancy or
intrauterine growth retardation(IUGR), our results suggest that it does not have a significant
effect on fetal growth in offsprings of mothers who have normal glucose metabolism. |
| Key Words:
Umbilical Cord, C-peptide, Insulin, Anthropometric measures |
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