| Reappraisal of the Efficacy of Measles Vaccination |
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Sung Ho Cho, Hyo Geun Ju, Chang Hee Cho, Young Youn Choi, Jae Suk Ma, Tae Joo Hwang |
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Department of Pediatrics, College of Medicine, Chonnam University, Kwangju, Korea |
| 홍역 예방접종 효과의 재평가 |
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조성호, 주효근, 조창이, 최영륜, 마재숙, 황태주 |
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전남대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Measles is one of the most highly communicable infectious disease, but has become a rare disease with the widespread use of vaccine. Recently, however, resurgence of the disease in school aged or adolescents who had received the vaccine before or at the 15 month warrants reappraisal of the efficacy of the vaccination. The purpose of this study was to investigate positive prevalence of antibody and its quantitative titers in different age groups in order to determine necessity and appropriate time of booster vaccine.
Methods
: We measured measles antibody in the sera of 192 children from different age
groups(61 cases from 4-6 years of age, 40 cases from 8-9 years of age, 47 cases from 12-13 years of age, 44 cases from 15-16 years of age). Eight to ten children from each group were selected and quantitative antibody titers were measured by EIA(measles Ig G EIA SEIKEN) method.
Results
: 1) The positive prevalence of measles antibody in four to six year age group(72%) was significantly lower than the expected positive prevalence of measles antibody(95%) (p<0.001).
2) Median antibody titer in twelve to thirteen year age group tended to be relatively lower than the other age groups.
3) There was no significant differences in the positive prevalence of measles antibody and median titers between sex.
Conclusion
: This data supported that the booster vaccination be needed at four to six years of age. |
| Key Words:
Measlesantibody, Efficacy, Booster |
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