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A Case of Lymphocytic Interstitial Pneumonia

Journal of the Korean Pediatric Society 1997;40(4):572-577.
Published online April 15, 1997.
A Case of Lymphocytic Interstitial Pneumonia
Ho Young Lee, Hwang Min Kim, Mee Kyung Namgoong, Jong Soo Kim, Soon Hee Jung, Dong Jin Kim
Department of Pediatrics, Yonsei University, Wonju College of Medicine, Wonju, Korea
A Case of Lymphocytic Interstitial Pneumonia 1례
이호영, 김황민, 남궁미경, 김종수, 정순희, 김동진
연세대학교 원주의과대학 소아과학교실
Lymphoid interstitial pneumonia(LIP) is an uncommon process in childhood, and is characterized by interstitial accumulation of mature lymphocytes, plasma cells and reticuloendothelial cells. LIP is believed to have autoimmune or immunologic pathogenesis, because it is frequently associated with acquired immune deficiency syndrome, Epstein-Barr virus infection, common variable immunodeficiency. The patient described in this report had idiopathic thrombocytopenic purpura, Evans syndrome and LIP. The diminished levels of IgG1 & IgG2 were the only immunologic abnormality, which suggest that this patient may be in the early phase of common variable immunodeficiency or selective IgG2 & IgG4 deficiency due to immunoglobulin heavy chain deletion. We can rule out the possibility of lymphoma by clonality study, which showed polyclonal lymphocyte infiltration. On our knowledge, this is the first report of LIP in Korean children.
Key Words: Lymphocytic interstitial pneumonia, IgG2 & IgG4 deficiency

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