| A Case of Chronic Granulomatous Disease Which is Improved by Interferon-γ Therapy |
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Jae Choon Kim, Soon Seong Park, Myung Ja Yun, Dong Hyuk Keum |
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Department of Pediatrics, Kangbuk Samsung Hospital, Seoul, Korea |
| 감마 인터페론 치료로 호전을 보인 만성 육아종 질환 1례 |
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김재춘, 박순성, 윤명자, 금동혁 |
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강북삼성병원 소아과 |
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| Abstract |
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Chronic granulomatous disease is a group of rare disorders characterized by a disease
of oxidative metabolism of phagocytes with deficit of antimicrobial activity. Also, it has
clinical features of chronic pyogenic infection, granuloma formation, hypergammaglobulinemia,
anemia and leukocytosis.
We experienced a case of chronic granulomatous disease with chronic recurrent infection,
hypergammaglobulinemia and liver abscess. It was confirmed by modified NBT test. The
result of patient' s NBT test was less than 11%. The patient received subcutaneous
injection of interferon-γ, 200 million unit(0.1mg/m2 of body surface area per dose), on three
consecutive days per week for 3 weeks and her symptom was improved.
Then, we report a case of chronic granulomatous disease which is improved by
interferon-γ therapy with brief review of literature. |
| Key Words:
Chronic granulomatous disease, Interferon-γ therapy |
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