Journal of the Korean Pediatric Society 1998;41(2):200-208.
Published online February 15, 1998.
Serum Pepsinogen Ⅰ, Ⅱ Levels and Upper Gastrointestinal Diseases in Children with H. pylori Infection
Je Woo Kim, Ki Sup Chung
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
소아에서 Helicobacter pylori 감염 유무 및 내시경으로 진단된 상부위장관 질환별 혈청 Pepsinogen Ⅰ 및 Ⅱ치에 대한 연구
김제우, 정기섭
연세대학교 의과대학 소아과학교실
Correspondence: 
Ki Sup Chung, Email: 1
Abstract
Purpose
: In H. pylori infection serum pepsinogen Ⅰ/Ⅱ ratio decreases and pepsinogen Ⅱ level is increased. Increased serum pepsinogen Ⅱ level correlates with pathologic severity of gastritis. We assayed serum pepsinogen Ⅰ, Ⅱ levels and pepsinogen Ⅰ/Ⅱ ratio to evaluate the relationship between the serum pepsinogen level and upper gastrointestinal diseases.
Methods
: One hundred and sixty-five children who had undergone upper gastrodudenal endoscopic examination with CLO test and silver stain were included. Pepsinogen Ⅰ and Ⅱ levels were detected in serum by radioimmunoassay.
Results
: Age distributions were : 3 patients below 5 years, 55 patients between 6 and 10 and 107 over 11. Thirty-two(19%) were H. pylori positive, and 133(81%) were negative. Pepsinogen Ⅰ increased in H. pylori positive children(P<0.01). Pepsinogen Ⅱ were higher in the H. pylori positive patients compared to Helicobactor negative group(P<0.001). Pepsinogen Ⅰand Ⅱ were significantly higher(P<0.01 in pepsinogene Ⅰ: P<0.01 in Ⅱ) in children with nodular gastritis with Helicobactor positive than any other disease including H. pylori negative without duodenal ulcer. Pepsinogen Ⅰ/Ⅱ ratio was lower in children with nodular gastritis with H. pylori positive(P<0.001) than in children with any other disease including Helicobacter negative.
Conclusion
: These results suggest that serum pepsinogen levels are inportnat in pathogenesis of upper gastrointestinal disease in children with H. pylori infection.
Key Words: H. pylori, Serum pepsinogen Ⅰ and Ⅱ levels, Upper gastrointestinal disease


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