| Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia |
|
Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn |
|
Division of Hemato-oncology, Department of Pediatrics, Seoul National University, College of Medicine, Seoul, Korea |
| 소아 급성 골수성 백혈병에서 BH-AC, Idarubicin, 6-Thioguanine 관해유도요법의 치료성적 |
|
한효정, 강형진, 이준아, 최형수, 박현진, 성기웅, 유은선, 신희영, 안효섭 |
|
서울대학교 의과대학 소아과학교실 |
Correspondence:
Hyo Jeong Han, Email: 1
|
|
|
|
|
| Abstract |
Purpose
: We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG).
Methods
: BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment.
Results
: Complete remission(CR) was achieved in 18 cases(66.7%), partial remission(PR) was achieved in 2 cases(7.4%). In previously untreated patients, complete reimission rate was 92.9%(13/ 14), in relapsed patients, 40%(2/5) and in the refractory patients, 37.5%(3/8). The remission duration until December 1996 was 45 to 630 days(median 133). Duration of the neutropenia(ANC<500/μL) was 0 to 38 days(median 24). Side effects were nausea, vomiting(7/27, 25.9%), liver dysfunction(1/27, 3.7%), skin eruption(1/27, 3.7%), and mucositis(1/27, 3.7%). In all cases, fever developed in the neutropenic state(culture proven sepsis in 5 cases). Death occurred in 5 cases who achieved CR due to sepsis after chemotherapy(4 cases), intracerebral hemorrhage after bone marrow relapse (1 case).
Conclusion
: BH-AC, idarubicin, and 6-TG induction chemotherapy could be a useful induction chemotherapy treatment that combines supportive care for infection and bleeding. |
| Key Words:
BH-AC, Idarubicin, Induction chemotherapy, Remission rate, Acute myelogenous leukemia |
|
PDF Links
Download Citation
