Journal of the Korean Pediatric Society 1998;41(3):420-424.
Published online March 15, 1998.
A Case of Secondary Hemosiderosis and Hepatic Fibrosis in a Pateint with Acute Myelogenous Leukemia
Hyoung No Kim, Jae Won Huh, , , Jae Sun Park
Department of Pediatrics, Gospel Hospital, Kosin University, Pusan, Korea.
급성 골수성 백혈병 환아에서 수혈후 혈철증에 의한 간섬유화 1예
김형노, 허재원, 장희경, 허방, 박재선
고신대학교 의과대학 소아과학교실
Correspondence: 
Hyoung No Kim, Email: 1
Abstract
Chronic iron overload is associated with life-threatening complications, such as cardiomyopathy, liver cirrhosis, diabetes, hypothyroidism, hypoparathyroidism and hypogonadism. We experienced a case of secondary hemosiderosis with hepatic fibrosis in a 8-year-old boy who had been transfused 56 pints of packed red blood cells for a supportive therapy of acute myelogenous leukemia for a 27-month period. Intramuscular injection of Desferroxamine(40mg/kg/day) was done for 9 months, however, there was no sign of improvement in hepatic size, consistency, and in liver biopsy findings. Except for mild thrmobocytopenia which seems to be the result of hypersplenism, the boy remained in remission for 3 2/3 years. We think, the prompt use of Desferroxamine therapy may be needed to avoid iron overload, if patients recieved multiple transfusions and high serum ferritin level.
Key Words: Acute myeloid leukemia, Blood transfusion, Hepatic fibrosis, Desferroxamine


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