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Fatal Doudenal Ulcer Bleeding in Status Asthmaticus Treated with Theophylline and Steroids

Journal of the Korean Pediatric Society 1998;41(4):548-552.
Published online April 15, 1998.
Fatal Doudenal Ulcer Bleeding in Status Asthmaticus Treated with Theophylline and Steroids
Sang Woo Lee, Chang Keun Kim, Churl Young Chung, Young Doug Kim
Department of Pediatrics, College of Medicine, Inje University Sanggye Paik Hospital, Korea
Theophylline과 Steroid로 치료받은 천식환아의 Theophylline과 Steroid로 치료받은 천식환아의
이상우, 김창근, 정철영, 김영덕
인제대학교 의과대학 상계백병원 소아과학교실
Correspondence: 
Sang Woo Lee, Email: 1
Abstract
It is generally agreed that theophylline preparations and steroids should be given intravenously for status asthmaticus. Theophylline can potentially have adverse gastrointestinal effects including abdominal pain, nausea, vomiting, and hematemesis. Upper gastrointestinal bleeding in patients treated with corticosteroids without a past history of upper gastrointestinal bleeding has been reported rarely. But the etiologic significance of the stress of status asthmaticus, administration of theophylline or corticosteroids in the development of ulcer has been open to question. We report a case of 8-year-old boy with status asthmaticus treated with these medications and later found to have a bleeding duodenal ulcer for which emergency surgery was necessary.
Key Words: Theophylline, Steroids, Status asthmaticus, Bleeding duodenal ulcer


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