| A Clinical Study of Antithrombin Ⅲ Therapy for Disseminated Intravascular Coagulation in Neonates |
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Ji Young Kim, Cheong Nyen Kim, Myoung Jae Chey, Cheol Young Cheong |
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Department of Pediatrics, Inje University, College of Medicine Sanggye Paik Hospital, Seoul, Korea |
| 신생아에서의 범발성 혈관내 응고증에 대한 안티트롬빈 Ⅲ 농축제제의 효과 |
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김지영, 김정년, 최명재, 정철영 |
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인제대학교 의과대학 상계백병원 소아과 |
Correspondence:
Ji Young Kim, Email: 1
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| Abstract |
Purpose
: The purpose of this study is to evaluate the clinical effect of antithrombin Ⅲ concentrates in disseminated intravascular coagulation(DIC) of neonates.
Methods
: We reviewed the clinical records of 11 newborn patients who had been admitted and diagnosed as DIC at the neonatal intensive care unit of Sanggye Paik Hospital from November, 1995 to September, 1996.
Results
: There were 6 males and 5 females. In 9 cases(81.8%), gestational age was less than 37 weeks and birth weight was less than 2,500g. Sepsis was the most common underlying disease in 9 cases(81.8%), followed by respiratory distress syndrome, necrotizing enterocolitis, and fulminant hepatitis. The etiologic organisms of sepsis, were gram negative organisms, fungus, and gram positive organisms in decreasing order. There were signs of gastrointestinal tract hemorrhage, pulmonary hemorrhage, and intracranial hemorrhage as a result of DIC. In the clinical outcome of DIC patients, 6 out of 11 patients survived(54.5%).
Conclusion
: Administration of antithrombin Ⅲ concentrates in DIC of neonates produces improvement of clinical course and survival. |
| Key Words:
Antithrombin Ⅲ, Disseminated intravascular coagulation |
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