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Effects of Patent Ductus Arteriosus on Right Ventricle in Premature Infants : by M-mode and Doppler Echocardiography

Journal of the Korean Pediatric Society 1998;41(6):734-740.
Published online June 15, 1998.
Effects of Patent Ductus Arteriosus on Right Ventricle in Premature Infants : by M-mode and Doppler Echocardiography
Eun Jeung Kim, Eun Sil Lee, Young Hwan Lee, Son Moon Shin, Jeong Ok Hah
Department of Pediatrics, School of Medicine, Yeungnam University, Taegu, Korea
미숙아의 동맥관 개존이 우심실에 미치는 영향 :도플러 심초음파도를 이용한 연구
김은정, 이은실, 이영환, 신손문, 하정옥
영남대학교 의과대학 소아과학교실
Correspondence: 
Eun Sil Lee, Email: 1
Abstract
Purpose
: Patent ductus arteriosus, derived left to right shunt flows, elevate the pulmonary artery pressure in infants and children and may alter right ventricular afterload thereby right ventricular function. Therefore, we examined the effects of patent ductus arteriosus on the right ventricular systolic time interval in premature infants by non-invasive Doppler echocardiography.
Methods
: Tweleve premature infants with patent ductus arteriosus were studied by M-mode and Doppler echocardiography before and after treatment with mefenamic acid. Heart rate(HR), ratio of left atrium/aorta(LA/AO), right ventricular preejection period (RVPEP), right ventricular ejection time(RVET) and right ventricular systolic time interval(RVSTI : ratio of RVPEP/RVET), both corrected or uncorrected for heart rate were measured.
Results
: After mefenamic acid treatment, in infants showing clinical response, right ventricular preejection period(RVPEP) and right ventricular systolic time intetrval(RVSTI), both corrected or uncorrected for heart rate, decreased significantly following ductal closure(RVPEP : 70.3msecc¡¾14.5 vs 54.3msec¡¾10.9, P < 0.01, RVPEPc : 129.2msec¡¾13.5 vs 111.7msec¡¾8.4, P < 0.01, RVSTI : 0.38¡¾0.09 vs 0.28¡¾0.05, P < 0.05, RVSTIc : 0.31¡¾0.04 vs 0.27¡¾0.03, P < 0.01).
Conclusion
: Premature infants with patent ductus arteriosus exhibit echocardiographic evidence of increased RVSTI as a result of increased right ventricular afterload. This results suggest that we have to make every effort to prevent the ductal reopening or early closure of ductus arteriosus in premature infants.
Key Words: Right ventricular systolic time interval, Patent ductus arteriosus, Premature infants


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