| The Effect of Measles Vaccination Before Turning 1 Year-old on the Measles Antibody Response to Immunization with MMR |
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Soo Jung Choi1, Young Jae Koh1, Young Mo Soh2, Hoan Jong Lee3, Sung Hee Oh1 |
1Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
2Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
3Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea |
| 1세 이전의 홍역 예방접종이 홍역․볼거리․풍진 혼합백신 접종의 홍역 항체반응에 미치는 효과 |
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최수정1, 고영재1, 손영모2, 이환종3, 오성희1 |
1한양대학교 의과대학 소아과학교실
2연세대학교 의과대학 소아과학교실
3서울대학교 의과대학 소아과학교실 |
Correspondence:
Soo Jung Choi, Email: 1
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| Abstract |
Purpose
: With the implementation of measles vaccination programs, the number of patients with measles has decreased. However, epidemics still occur with high morbidity in infants less than 1 year of age. This fact calls for the establishment of optimal preventive measures against measles. The study was carried out to determine the effect of measles vaccination on an infant immunized before one year of age, any the measles immunity conferred by MMR.
Methods
: Seventy-seven healthy infants(13.7¡¾1.8 months) were immunized with the MMR vaccine(Triviraten BernaⓇ : Edmonston-Zagreb strain, Rubini strain, Wistar RA 27/3 strain), 50 of the infants have received measles vaccine before turning one-year old. The antibody titers of measles-specific IgG were measured by enzyme immunoassay.
Results
: The antibody titers before and after MMR vaccination were significantly higher in infants previously immunized with measles vaccine compared to those not immunized. However, the greater number of infants not previously immunized with measles vaccine showed significant increase of measles antibody titers after MMR vaccination compared to those previously immunized with measles vaccine. Measles vaccine failure occurred in 6 infants(12.0%), all of whom acquired measles immunity following MMR vaccination. Measles immunogenicity to MMR did not differ with respect to the age of previous measles vaccination.
Conclusion
: The results indicate that measles vaccination in infants less than 1 year of age will not decrease the measles immunity following MMR vaccination, and it is suitable to vaccinate against measles in infants between 6-12 months of age, if needed. |
| Key Words:
Measles, MMR, Vaccination, Measles immunity |
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