Journal of the Korean Pediatric Society 1998;41(7):979-983.
Published online July 15, 1998.
A Case of Type I Autoimmune Hepatitis in Children
Soeng Hun Kim, Su Eun Park, Jeong Hwa Choi, Jae Hong Park, Su Yung Kim
Department of Pediatrics, College of Medicine, Pusan National University, Pusan, Korea
소아에서의 1형 자가면역성 간염 1례
김성훈, 박수은, 최정화, 박재홍, 김수영
부산대학교 의과대학 소아과학교실
Correspondence: 
Soeng Hun Kim, Email: 1
Abstract
Autoimmune hepatitis is an inflammatory liver disease characterized histologically by a dense mononuclaear cell infiltration of the portal tract, serologically by the presence of non-organ and liver specific autoantibodies and increased concentrations of IgG in the absence of a known etiology. Two types of autoimmune hepatitis are classified in the peripheral blood of antinuclear antibody and/or in antismooth muscle antibody(ANA/ASMA) or liver-kidney microsomal type 1 antibody(LKM-1). Type I(ANA/ASMA positive) and type II(LKM-1 positive) autoimmune hepatitis in children have clinical, biochemical, and histologic differences. We have experienced a case of type I autoimmune hepatitis in a 9-year-old girl. She had shown highly elevated IgG, high serum transaminase and marked hepatosplenomegaly. And so serologically ANA and ASMA were positive, histological findings of the liver biopsy were compatible with chronic active hepatitis. She was medicated with prednisone, but symptoms did not improved. Now she is receving conservative regimens.
Key Words: Type I autoimmune hepatitis


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