Journal of the Korean Pediatric Society 1998;41(9):1273-1282.
Published online September 15, 1998.
The Significance of Family History, Immunoglobulin E, Total Eosinophils and Eosinophil Cationic Protein as a Predictor of Allergic Diseases
Dong Su Park, Hyun Hee Kim, Joon Sung Lee
Department of Pediatrics, Catholic University Medical College, Seoul, Korea
알레르기 질환 발생 예견인자로서 가족력, Immunoglobulin E, 총호산구수 및 Eosinophil Cationic Protein의 의의
박동수, 김현희, 이준성
가톨릭대학교 의과대학 소아과학교실
Correspondence: 
Dong Su Park, Email: 1
Abstract
Purpose
: Family history of allergy and cord blood immunoglobulin E concentration have been proven to be predictors of the development of allergic diseases in children. The purpose of this study is to evaluate whether maternal, cord and baby's blood total eosinophils or eosinophil cationic protein(ECP) in addition to the above two predictors could be a predictor of subsequent allergic diseases later in life.
Methods
: Fifty pregnant women and their newborns with positive family history of allergic disease and fifty other pregnant women and their newborns with no family history were investigated and a clinical follow-up study was conducted in thirty-two infants for two years. Immunoglobulin E level, total eosinophils and ECP level were measured in maternal, cord and baby's blood.
Results
: The group who developed allergic disease showed significantly high cord immunoglobulin E concentration than the group who did not develop allergic disease(P<0.01). There were no significant differences of immunoglobulin E level, total eosinophils, ECP level in maternal, cord, baby's blood between the group with positive family history of allergic disease and the group with no family history. The incidence of allergic disease was significantly higher in the group which had both positive family history and high cord blood immunoglobulin E concentration than the group which had no family history and low cord blood immunoglobulin E concentration(P<0.01).
Conclusion
: Family history of allergy and high-cord blood immunoglobulin E concentration are the best predictors of allergic diseases later in life.
Key Words: Allergic disease, Family history, IgE, Eosinophil, Eosinophil cationic protein


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