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A Case of Inappropriate ADH Secretion Secondary to Vinblastine Therapy

Journal of the Korean Pediatric Society 1998;41(10):1430-1432.
Published online October 15, 1998.
A Case of Inappropriate ADH Secretion Secondary to Vinblastine Therapy
Eun-Hye Park1, Hyun-Sang Cho2, Hae-Sook Yoo3, Chuhl-Joo Lyu1, Chang-Hyun Yang1, Kir-Young Kim1
1Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
2Department of Pediatrics, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea
3Department of Pediatrics, Kunpo Medical Center, College of Medicine, Wonkwang University, Kunpo, Korea
Vinblastine 투여후 합병된 항이뇨호르몬 과다분비 증후군 1례
박은혜1, 조현상2, 유해숙3, 유철주1, 양창현1, 김길영1
1연세대학교 의과대학 소아과학교실
2한림대학교 의과대학 강동성심병원 소아과
3원광대학교 의과대학 군포병원 소아과
Eun-Hye Park, Email: 1
Inappropriate secretion of antidiuretic hormone(ADH) secondary to vincristine therapy has been reported frequently. But there has been five previous reports of vinblastine associated SIADH in the world and in 4 reports, bleomycin and cis-platinum were used along with vinblastine together. Because penetration of vinka alkaloids into CSF of humans is known to be poor, it has been suggested that lowering the osmotic threshold for vasopressin release induces SIADH in humans. In our case, the patient did not receive cis-platinum during chemotherapy. From this we concluded that vinblastine alone can induce SIADH without nephrotoxicity of cis-platinum. We experienced a case of inappropriate ADH secretion secondary to vinblastine therapy in a 5- month-old male infant who has been taking vinblastine due to Langerhans cell histiocytosis. We report this case with a brief review of related literatures.
Key Words: Vinblastine, SIADH

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