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Relationship between Chest Radiography and Cell-mediated Immunity in Mycoplasma pneumoniae Pneumonia

Journal of the Korean Pediatric Society 1998;41(11):1509-1516.
Published online November 15, 1998.
Relationship between Chest Radiography and Cell-mediated Immunity in Mycoplasma pneumoniae Pneumonia
Yong Dae Ham, Jae Il Yoo, Jin Hwa Jeong, Jeong Ho Lee, Jong Dae Cho
Department of Pediatrics, Maryknoll Hospital, Pusan, Korea
Mycoplasma pneumoniae 폐렴의 흉부 방사선소견과 세포매개형 면역반응과의 관계에 대한 연구
함용대, 유재일, 정진화, 이정호, 조종대
부산 메리놀병원 소아과
Correspondence: 
Yong Dae Ham, Email: 1
Abstract
Purpose
: Mycoplasma pneumoniae pneumonias have been one of the most common causes of lower respiratory tract diseases during childhood. It is suggested that pathologic changes seen in the lung tissues were the histologic expression of the host immune response. The aim of this study was to determine the relationship between the chest radiographic pattern of Mycoplasma pneumoniae pneumonia and the level of the cell-mediated immunity of the host.
Methods
: Chest radiographic changes and the results of tuberculin skin test(5TU PPD) were studied during the acute stage of infection in 76 patients with Mycoplasma pneumoniae pneumonia. Chest radiographic findings were used to divide the patients into two groups; one group had a predominance of diffuse reticulonodular infiltration(Group A; n=40), while the remainings showed a predominance of segmental or lobar consolidation(Group B; n=36). A comparison was made between the two groups in terms of age, gender, total leukocyte and lymphocyte count, mycoplasma antibody titer, severity of pneumonia, and pleural effusion.
Results
: Sixty out of 70 patients had negative tuberculin skin test and the positive rate of PPD reaction was higher in Group A(14/40) compared to Group B(2/40)(P<0.05). Pleural effusion was observed significantly more often in Group B(10/36) than in Group A(2/40)(P<0.05). There was no significant difference between Group A and B in age, gender, total leukocyte and lymphocyte count, mycoplasma antibody titer and severity of the disease(P>0.05).
Conclusion
: Our study suggests that the cell-mediated immunity of patients with Mycoplasma pneumoniae pneumonia might influence the radiographic pattern of the pulmonary lesions.
Key Words: Cellular immunity, Mycoplasma pneumoniae, Tuberculin test


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