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Serum Levels of Insulin-Like Growth Factor-Ⅰ and Insulin-Like Growth Factor Binding Protein-3 between Short Children with or without Intrauterine Growth Retardation

Journal of the Korean Pediatric Society 1999;42(3):390-396.
Published online March 15, 1999.
Serum Levels of Insulin-Like Growth Factor-Ⅰ and Insulin-Like Growth Factor Binding Protein-3 between Short Children with or without Intrauterine Growth Retardation
Kye Shik Shim, Se Young Kim, Choong Ho Shin, Sei Won Yang
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
자궁내 성장지연증으로 인한 저신장증 소아와 가족성 저신장증 소아에서 인슐린양 성장인자-Ⅰ과 인슐린양 성장인자 결합단백-3의 혈중 농도의 비교
심계식, 김세영, 신충호, 양세원
서울대학교 의과대학 소아과학교실
Abstract
Purpose
: Postnatally, 20% of children with intrauterine growth retardation(IUGR) has no catch- up growth, This might be dependent on the serum level of Insulin-like growth factor I(IGF-I), resulting in shortness. We measured serum levels of IGF-I and Insulin-like growth factor binding protein-3(IGFBP-3) in children with IUGR and normal short stature variants(NSSV) to observe whether they play a role in catch-up growth for children with IUGR or not.
Methods
: Our study included 19 children with IUGR and 15 children with NSSV. We measured height, bone age, serum levels of IGF-I and IGFBP-3 using ELISA kit.
Results
: Mean age of IUGR and NSSV were 6.25¡¾1.75 and 6.32¡¾1.75 years, respectively. All of them were prepubertal. The height standard deviation score in IUGR and NSSV were -2.36¡¾1.01 and -1.38¡¾0.51, respectively(P<0.05). Serum IGF-I levels in IUGR and NSSV were 77.12¡¾78.04ng/mL and 113.99¡¾103.13ng/mL, respectively(P>0.05) and serum IGFBP-3 levels in IUGR and NSSV were 3441¡¾1358ng/mL and 4553¡¾3345ng/mL, respectively(P>0.05). In children younger than 5years old, serum IGF-I levels in IUGR and NSSV were 52.71¡¾35.3ng/mL and 107.75¡¾61.6ng/mL, respectively(P<0.05) and serum IGFBP-3 levels in IUGR and NSSV were 3028¡¾418.4 ng/mL and 4589¡¾2684ng/mL, respectively(P>0.05). There were significant correlations between height standard deviation scores and serum IGF-I levels in children with IUGR under the age of 5 years(r=0.60, P<0.05), also height standard deviation scores and serum IGFBP-3 levels in children with IUGR and NSSV under the age of 5 years(r=0.50, P<0.05, r=0.52, P<0.05, respectively).
Conclusion
: The results suggest that low levels of IGF-I and IGFBP-3 do not cause short stature in children with IUGR. However, low levels of IGF-I probably cause short stature in infancy and early childhood with IUGR, which remains to be clarified with further study.
Key Words: Intrauterine growth retardation, Short stature, IGF-I, IGFBP-3


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