| Pulmonary Inflammatory Cells in Preterm Infants with Respiratory Distress Syndrome Followed by Surfactant Treatment |
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Hyeon-Soo Lee1, Myung-Seo Kang2 |
1Department of Pediatrics, Pundang Jesaeng General Hospital,Sungnam, Korea
2Department of Clinical Pathology, Pundang CHA Geneneral Hospital, Sungnam, Korea |
| 미숙아 호흡곤란증후군에 있어서 인공 폐계면활성제 투여에 따른 폐 세포의 변화 |
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이현수1, 강명서2 |
1분당 제생병원 소아과
2분당 차병원 임상병리과 |
Correspondence:
Hyeon-Soo Lee, Email: 1
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| Abstract |
Purpose
: The effect of surfactant treatment on inflammatory cell populations has not been determined. I evaluated the effect of surfactant treatment on a number and distribution of inflammatory cells in bronchoalveolar lavage fluid(BALF) from the preterm infants who were dependent on mechanical ventilation over the 1st week of life.
Methods
: This study included 8 preterm infants with respiratory distress syndrome(RDS) who received surfactant(Exosurf, 67.5mg/kg Dipalmitoyl phosphatidylcholine(DPPC) with a volume of 5 ml/kg, single dose)on their first day of life and 7 preterm infants of similar severity who did not. BALFs were collected on days 2, 3, 5, and 7 after birth. Cell counts were performed from the obtained BALFs, then they were applied to cytospin and Wright stain, and the differentials were calculated on 200 cells.
Results
: Surfactant treatment had no significant effect on the number of BALF white cells on days 2-7. Polymorphonuclear cell numbers were not different in both groups on days 2 7. Macrophage cell numbers were higher overall in surfactant treated babies compared to those in untreated babies on days 2-7(P<0.05).
Conclusion
: Surfactant treatment appeared to accelerate the appearance of macrophages in BALF. |
| Key Words:
Inflammatory cells, Macrophage, Respiratory distress syndrme, Bronchoalveolar lavage fluid |
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