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The Relation of Food-Specific IgE to Recurrent Wheezing Attack

Journal of the Korean Pediatric Society 1999;42(8):1056-1062.
Published online August 15, 1999.
The Relation of Food-Specific IgE to Recurrent Wheezing Attack
Yun Jeong Yang, Jeong Hee Kim, Yoo Mee Choi, Dae Hyun Lim, Sei Woo Chung, Jeong Gyu Kim, Byong Kwan Son
Department of Pediatrics, College of Medicine, Inha Hospital, Seongnam, Korea
식품항원 특이 IgE와 천명 재발의 관계
양윤정, 김정희, 최유미, 임대현, 정세우, 김정규, 손병관
인하대학교 의과대학 소아과학교실
Jeong Hee Kim, Email: 1
: There were some reports that IgE-mediated food hypersensitivity is associated with subsequent development of atopic disease in wheezy infants. So we carried out this study to show whether the food specific IgE antibodies are useful to predict recurrent wheezing attack in wheezy infants.
: A total of 190 children younger than 4-year-old were enrolled in this study. They were divided into 3 groups according to the number of experienced wheezing attacks as 1st, 2nd and more than 3rd attack group. There were 30 age-matched controls who had not wheezing nor family members of allergy. We measured peripheral blood eosinophil count, total serum IgE level, RAST f1(egg white), f2(milk), D1(Dp) and D2(Df) from the all participants.
: The proportion of patients having more than 250/mm3 cosinophils in each group increased as increasing wheezing attacks(P<0.05). The geometric mean of total serum IgE levels were 1.58¡¾0.71IU/ml, 1.33¡¾0.80IU/ml, 1.71¡¾0.72IU/ml and 1.65¡¾0.57IU/ml in control, 1st, 2nd, and more than 3rd wheezing attack groups respectively, and it did not increased significantly as the number of wheezing attacks increased(P>0.05). There was no significant difference in RAST f1 levels among the four groups. In contrast, the proportion of positive RAST f1 increased significantly as the number of wheezing attacks increased(P<0.05). There were no significant differences in the percentage of positive RAST f2, d1 and d2 among the four groups(P>0.05).
: Egg white specific IgE antibody appear to be a risk factor for recurrent wheezing in infants and young child.
Key Words: Wheezing, Food antigen specific IgE, Asthma

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