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A Study of Factors Affecting Time of First Stool in Premature Infants

Journal of the Korean Pediatric Society 1999;42(12):1645-1650.
Published online December 15, 1999.
A Study of Factors Affecting Time of First Stool in Premature Infants
Hyeong Doo Cho, Je Woo Kim, Young Ah Lee, Hae Sun Yoon
Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
미숙아의 첫 대변배출시간에 영향을 주는 인자에 대한 연구
조형두, 김제우, 이영아, 윤혜선
한림대학교 의과대학 소아과학교실
Hyeong Doo Cho, Email: 1
: To assess the effect of gestational age and illness severity, and the effect of antenatal exposure to magnesium sulfate, glucocorticoids, and antibiotics, on the timing of the first stool in preterm infants.
: Medical records of all preterm infants admitted to the neonatal ward at Kangnam Sacred Heart Hospital between March 1998 and August 1998 were reviewed. We studied the time of the first stool in 55 infants.
: The median age of the infant at the time of first stool was 18 hours, and 90% of the infants passed stool by 50 hours. Both the gestational age and the illness severity, as measured by the score for neonatal acute physiology(SNAP), correlated significantly with the timing of the first stool(r=0.47 and P < 0.001 for SNAP; r=0.29 and P < 0.05 for gestational age). An analysis of covariance showed that the relationship between SNAP and the timing of the first stool was significant even after adjustment for gestational age(P < 0.01), but the relationship between the gestational age and the timing of the first stool was not significant after adjustment for SNAP (P =0.14). Antenatal exposure to magnesium sulfate for tocolysis, glucocorticoids for enhancing fetal lung maturity, and antibiotics, had no effect on the timing of the first stool.
: Delayed passage of first stool is a function of illness severity, not of gestational immaturity. Antenatal exposure to magnisium sulfate, dexamethasone, and antibiotics, does not affect the timing of first stool in premature infants.
Key Words: Illness severity, Gestational age, Timing of first stool, Magnesium sulfate, Dexamethasone, Antibiotics, Preterm infant, SNAP

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