| Changes of Interleukin-10 and Granulocyte Colony-Stimulating Factor in Cerebrospinal Fluid of Children with Aseptic Meningitis |
|
Byeong Chan Park1, Jung-Yeon Shim1, Jeong Mi Lee1, Jin-Young Park1, Myung Ja Yoon1, Hye Rim Jung1, Moon Soo Park1, Dong Hyeuk Keum1, Dong Keug Keum2 |
1Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
2Department of Clinical Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea |
| 무균성 뇌막염 소아에서 뇌척수액 Interleukin-10과 Granulocyte Colony-Stimulating Factor의 변화 |
|
박병찬1, 심정연1, 이정미1, 박진영1, 윤명자1, 정혜림1, 박문수1, 금동혁1, 금동극2 |
1성균관대학교 의과대학 강북삼성병원 소아과
2성균관대학교 의과대학 강북삼성병원 임상병리과 |
Correspondence:
Jung-Yeon Shim, Email: 1
|
|
|
|
|
| Abstract |
Purpose
: Interleukin(IL)-10 is an antiinflammatory cytokine produced by monocytes/macrophages. Granulocyte colony-stimulating factor(G-CSF) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils, in the foci of infection. We studied G-CSF and IL-10 levels in the serum and cerebrospinal fluid(CSF) of patients with aseptic meningitis and investigated the relationship of G-CSF and IL-10 with other inflammatory cells.
Methods
: We measured IL-10 and G-CSF levels in the serum and CSF of children with or
without aseptic meningitis using ELISA and compared them with other inflammatory cells in the CSF.
Results
: CSF levels of IL-10 & G-CSF on admission were significantly higher in the aseptic meningitis group than in the control group. IL-10 and G-CSF levels in the CSF were higher than those in the serum(P < 0.001). Mean CSF IL-10 & G-CSF levels during the recovery stage decreased significantly compared to those of the symptomatic stage(P < 0.001). Significant correlations were found between CSF IL-10 levels and mononuclear cell counts(r=0.26, P <0.05), and between G-CSF levels and neutrophil counts in the CSF(r=0.44, P < 0.005). CSF levels of G-CSF were highest on the 1st day of the illness, although CSF IL-10 levels reached its peak on the 3rd day
of the illness.
Conclusion
: IL-10 and G-CSF are produced in the CSF of patients with aseptic meningitis and may play an immunoregulatory role by recruiting inflammatory cells from the peripheral blood at the initial stage of aseptic meningitis. |
| Key Words:
Aseptic meningitis, G-CSF, IL-10 |
|
PDF Links
Download Citation
