| 6 Cases of Transient Hyperphosphatasemia of Infancy and Early Childhood |
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Jong Gon Oh, Dong Hyeon Choi, Kyung Eun Oh, Moon Ki Cho, Chul Sohn |
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Department of Pediatrics, St. Columban`s Hospital, Mokpo, Korea |
| 영아기와 학동전기의 일과성 고인산효소혈증 6례 |
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오종곤, 최동현, 오경은, 조문기, 손 철 |
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성골롬반병원 소아과 |
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| Abstract |
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Sometimes physicians and clinical pathologists find very high levels of alkaline phosphatase(ALP)
activity in their patients. This condition is associated with transient, marked increase in serum
ALP in healthy infants and children. It has also been described in adults. Clinical and biochemical
features of transient hyperphosphatasemia in infancy and early childhood are reviewed in six
patients that we have studied. The diagnosis is suggested by findings of increased activity of
alkaline phosphatase in plasma, typically more than fivefold the upper reference value for adult, in
a child under five years of age, without evidence of liver or bone disease. The condition is
confirmed by the presence of a characteristic pattern of alkaline phosphatase isoenzymes and by
the normalization of enzyme activity in plasma within approximately six months after the original
observation. The etiology of the condition and possible mechanism of the elevated ALP is
discussed. |
| Key Words:
Alkaline phosphatase(ALP), Transient hyperphosphatasemia |
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