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The Relation between Antibiotic Use and Changes of Antimicrobial Resistance of Gram Negative Bacilli Isolated in Chonbuk National University Hospital(1993-1997)

Journal of the Korean Pediatric Society 2000;43(5):625-631.
Published online May 15, 2000.
The Relation between Antibiotic Use and Changes of Antimicrobial Resistance of Gram Negative Bacilli Isolated in Chonbuk National University Hospital(1993-1997)
Min Ki Chang1, Jung Min Chu1, Hae Soo Lee2, Jung Soo Kim1
1Department of Pediatrics, School of Medicine, Chonbuk National University, Chonju, Korea
2Department of Clinical Pathology, School of Medicine, Chonbuk National University, Chonju, Korea
전북대학교병원에서 분리된 그람음성균의 항생제 내성률의 변동과 약물 사용과의 관계
장민기1, 추정민1, 이혜수2, 김정수1
1전북대학교 의과대학 소아과학교실
2전북대학교 의과대학 임상병리과학교실
Abstract
Purpose
: Antimicrobial resistance has become a major medical and public health problem. This study was performed to evaluate the changes in antimicrobial susceptibility patterns.
Methods
: The susceptibility of 8,224 recent clinical isolates during a 5-year period from 1993 to 1997 were tested against 8 antimicrobial agents. Antimicrobial susceptibility test was performed by disc diffusion method.
Results
: E. coli was the most common clinical isolate followed by P. aeruginosa, K. pneumoniae, E. cloacae and S. marcescens. Results of susceptibility test were as follows. Most of the microbial isolates were highly resistant(>90%) to ampicillin. E. coli was susceptible to cefotaxime, ceftazidime and amikacin, but was highly resistant to penicillins. Resistance rate of E. coli to ceftazidime was gradually increased from 3% to 14% during the study period. P. aeruginosa was highly resistant to all kinds of antibiotics. K. pneumoniae was relatively sensitive to cephalosporins, aminoglycosides and ciprofloxacin, but showed high resistance to penicillins. E. cloacae was sensitive to ciprofloxacin and chloramphenicol. S. marcescens was also sensitive to ciprofloxacin, chloramphenicol and ceftazidime. Resistance to ceftazidime was gradually increased in E. coli, P. aeruginosa, E. cloacae and S. marcescens, while that of cefotaxime was rather decreased during the study period in E. coli, K. pneumoniae and E. colacae.
Conclusion
: Antimicrobial resistance of Gram-negative organisms gradually changed during the study period. Those changes, which were more significant in cephalosporins, generally correlated with the amount of antibiotics used.
Key Words: Antimicrobial resistance, Gram-negative bacilli, Antibiotics


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