| Characteristics of Childhood Asthma According to the
Onset of Wheezing |
|
Yoon Jeong Kim, Bong Seong Kim, Soo-Jong Hong |
|
Department of Pediatrics, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea |
| 천명 발생 시기에 따른 소아 천식의 특성 |
|
김윤정, 김봉성, 홍수종 |
|
울산대학교 의과대학 서울중앙병원 소아과 |
|
|
|
|
| Abstract |
Purpose
: To understand the characteristics of early childhood asthma, we evaluated and compared the characteristics between early persistent wheezers and late wheezers.
Methods
: From January, 1998 to December, 1998, 106 children aged six to seven years were divided into three groups according to the onset of wheezing : Early persistent wheezers(n=36) who had wheezing both before three years of age and at six, late wheezers(n=48) who had no wheezing before the age of three years but had wheezing at six years, and control group(n=22) who had never wheezed at the age of six years. We performed pulmonary function and methacholine challenge tests, and measured the concentration of serum total IgE, D. pteronyssinus & D. farinae-specific IgE and total eosinophil count in these children.
Results
: Early persistent wheezers had significantly diminished FEF25-75% than late wheezers and control group. Both early persistent wheezers and late wheezers had airway hyperresponsiveness to methacholine. Late wheezers had higher concentrations of serum total IgE than control group. The concentration of D. pteronyssinus and D. farinae-specific IgE and total eosinophil count were elevated significantly in early persistent wheezers and late wheezers than control group.
Conclusion
: Late wheezers are more closely related to atopy. Early persistent wheezers have diminished FEF25-75%, suggesting that early persistent wheezers may have abnormalities of peripheral airway. Therefore, these results strongly suggest that wheezing during childhood may be a heterogenous condition and there are apparently different two groups, early persistent wheezers and late onset wheezers, in childhood asthma. |
| Key Words:
Childhood asthma, Wheezing, Pulmonary function test, Airway hyperresponsiveness, IgE |
|
PDF Links
Download Citation
