| Infantile Hypertrophic Pyloric Stenosis Treated with Intravenous Atropine Sulfate |
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Jae Woo Lim1, Hee Sook Son1, Kye Shik Shim1, Kyu Chul Choeh1, Tae Il Han2 |
1Department of Pediatrics, Eulji Medical College, Taejon, Korea
2Department of Radiology, Eulji Medical College, Taejon, Korea |
| 영아 비후성 유문 협착증의 정맥내 아트로핀 치료 |
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임재우1, 손희숙1, 심계식1, 최규철1, 한태일2 |
1을지의과대학 소아과학교실
2을지의과대학 방사선과학교실 |
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| Abstract |
Purpose
: The pharmacologic effect of atropine on HPS can be considered to control pyloric muscle spasm. Therefore, we studied the effects of intravenous atropine sulfate on the clinical course of HPS, and periodically observed the ultrasonographic appearance of the pyloric muscles after atropine treatment.
Methods
: From April 1998 to May 1999, 14 infants who were diagnosed with HPS were treated with intravenous atropine sulfate. Intravenous atropine sulfate was administered at an initial dose of 0.04mg/kg/day, which was divided into 8 equal doses. The daily dose was increased by 0.01 mg/kg/day until vomiting was controlled for an entire day while infants received unrestricted oral feeding. Ultrasonographic examinations were performed during hospitalization and repeated at least every 2 months until normalization of pyloric muscles was confirmed.
Results
: Intravenous atropine was effective in 12 of 14 infants with HPS and the conditions of 9 of them improved. Two infants who were not free from vomiting despite a week of intravenous atropine sulfate treatment underwent pyloromyotomy. A series of ultrasonographic examinations were done after vomiting had improved with intravenous atropine sulfate. The ultrasonographic findings showed good passage of gastric contents through pyloric canals despite thickening of the pyloric muscles.
Conclusion
: Intravenous administration of atropine sulfate is an effective therapy for HPS and can be an alternative to pyloromyotomy. |
| Key Words:
Atropine sulfate, Intravenous, Hypertrophic pyloric stenosis |
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