| Insulin-like Growth Factor(IGF)-I and IGF-Binding Protein-3 in Relation to Hemoglobin Concentration in Healthy Infants |
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Yoon Ki Kang1, Dae-Yeol Lee2 |
1Department of P ediatrics, Chonbuk National University, M edical School, Chonbuk, Korea.
2Department of P ediatrics, Institute for M edical Science, Chonbuk National University, M edical School, Chonbuk, Korea |
| 건강한 영아에서 혈청 Insulin-like Growth Factor (IGF)-I, IGF Binding Protein(IGFBP)-3와 혈색소와의 관계 |
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강윤기1, 이대열2 |
1전북대학교 의과대학 소아과학교실
2전북대학교 의과대학 소아과학교실, 의과학연구소 |
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| Abstract |
Purpose
: Insulin-like growth factor(IGF-I) and IGF binding protein(IGFBP)-3 is thought to play
an important role in fetal erythropoiesis. The objective of this study was to establish a relation
between IGF-I, free IGF-I, IGFBP-1, and -3 with hemoglobin level in healthy term, 3-month, and
12-month old infants.
Methods
: Healthy term infants(n=20) were enrolled at birth, as well as 3 months(n=30) and 12
months(n=30) of age. The serum IGF-I concentrations were measured by a specific radioimmunoassay(
RIA), and the serum levels of free IGF-I, IGFBP-1 and -3 were measured by specific
immunoradiometric assay(IRMA) kit.
Results
: The mean level of hemoglobin was 15.6¡¾1.4g/dL, IGF-I was 14.5¡¾7.0ng/mL and IGFBP-3
was 1205.2¡¾292.1ng/mL at birth. Serum IGF-I, IGFBP-3 and hemoglobin concentrations were
correlated positively at birth(P < 0.01), and a positive correlation was observed between hemoglobin
and free IGF-I(P < 0.05). The mean level of hemoglobin was 10.7¡¾0.8g/dL, IGF-I was 27.3¡¾11.1
ng/mL and IGFBP-3 was 1674.1¡¾399.1ng/mL at three months of age. No correlation was observed
between hemoglobin and IGF-I, IGFBP-3 and free IGF-I. The mean level of hemoglobin was
10.6¡¾0.8g/dL, IGF-I was 45.5¡¾13.9ng/mL and IGFBP-3 was 2124.5¡¾401.8ng/mL at 12 months of age.
Conclusion
: Our results show that blood hemoglobin is positively correlated to serum IGF-I and
IGFBP-3 concentrations, indirectly indicating the involvement of mediators of growth hormone on
the regulation of physiologic hemoglobin concentration at birth. |
| Key Words:
Insulin-like growth factor(IGF)-I, IGF binding protein-3, Hemoglobin |
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