| A Case of T-cell Acute Lymphoblastic Leukemia presented with Spontaneous Tumor Lysis Syndrome and Superior Vena Cava Syndrome |
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Eun Jung Shim, Hyun-Sang Cho, Jae Kook Cha, Jae Kook Cha, Chong Young Park |
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Department of P ediatrics, College of M edicine, Hallym University, Seoul, Korea |
| 자발성 종양 용해 증후군과 상대정맥 증후군으로 발현된 T세포 급성 림프구성 백혈병 치료 경험 1례 |
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심은정, 조현상, 차재국, 김종완, 박종영 |
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한림대학교 의과대학 소아과학교실 |
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| Abstract |
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Acute spontaneous tumor lysis syndrome is a condition resulting from the rapid release of cellular
breakdown products into the circulation due to massive cytolysis occurring before start of treatment.
It occurs most often in Burkitt' s lymphoma and T-cell ALL, both of which have been well
described, following cytotoxic chemotherpy and other single agent administrations. However, only a
handful of spontaneous acute tumor lysis syndrome cases have recently been reported in the
literature. We have recently experienced a case of a T-cell ALL in a 9-year-old girl presented
with superior vena cava syndrome(SVC syndrome) and uric acid nephropathy due to acute
spontaneous tumor lysis syndrome. On admission, she had marked elevation in serum uric acid,
BUN and creatinine. She was given dexamethasone administration as a treatment of SVC
syndrome and was supported with allopurinol therapy, hyperhydration and alkalinization of urine.
On day 7 following continuous dexamethasone administration, her BUN and creatinine returned to
normal and no blast cells was found in peripheral blood. Then, ALL induction chemotherapy
(CCG-1882 protocol) was used, resulting in complete remission. |
| Key Words:
ALL, Spontaneous acute tumor lysis syndrome, Superior vena cava syndrome |
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