| Two Cases of Thin Basement Membrane Nephropathy presented with Minimal Change Nephrotic Syndrome |
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Young Mee Seo1, Jae Gul Chung2, En Sil Yu2, Jin Yeong Jeong3, Young Seo Park1 |
1Department of Pediatrics, Asan M edical Center
2Department of Diagnostic P athology, Asan M edical Center
3Department of Pediatrics, Ulsan University Hospital, College of Medicine, University of Ulsan |
| 미세변화 신증후군의 임상소견을 보인 비박형 기저막신증 2례 |
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서영미1, 정재걸2, 유은실2, 정진영3, 박영서1 |
1울산대학교 의과대학 서울중앙병원 소아과
2울산대학교 의과대학 서울중앙병원 진단병리과
3울산대학교병원 소아과 |
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| Abstract |
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Thin basement membrane nephropathy(TBMN) is defined histologically as follows : 1) By light microscopy only minor abnormalities are detected in the glomeruli at most minor mesangial widening. 2) By electron microscopy, diffuse thinning of glomerular basement membrane is demonstrated. 3) By immunofluorescence, absence of immunoglobulins and complement components is demonstrated. 4) Alport`s syndrome and systemic diseases that may affect the glomerular structure have been excluded. TBMN presented frequently with recurrent or persistent microscopic hematuria. Massive proteinuria such as in nephrotic syndrome rarely occurs in TBMN. We reported two cases of TBMN presented with typical minimal change nephrotic syndrome. |
| Key Words:
Thin basement membrane nephropathy, Minimal change nephrotic syndrome |
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