| Distribution of Anti-Mumps IgM Antibody in Children Presumptively Diagnosed of Mumps |
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Sung Hee Oh1, Do Hack Yum1, Jin Han Kang2, Young Mo Sohn3, Hoan Jong Lee4, Bok Yang Pyun5, Young Jin Hong6, Chang Hwi Kim5 |
1Department of Pediatrics, College of Medicine, Hanyang University, Korea
2Department of Pediatrics, The Catholic University of Korea, Korea
3Department of Pediatrics, College of Medicine, Yonsei University, Korea
4Department of Pediatrics, Seoul National University College of Medicine, Korea
5Department of Pediatrics, College of Medicine, Soonchunhyang University, Korea
5Department of Pediatrics, College of Medicine, Soonchunhyang University, Korea
6Department of Pediatrics, College of Medicine, Inha University￠O, Korea |
| 임상적으로 추정되는 볼거리 환아에서의 항 멈프스 IgM 특이항체의 분포 |
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오성희1, 염도학1, 강진한2, 손영모3, 이환종4, 편복양5, 홍영진6, 김창휘5 |
1한양대학교 의과대학 소아과학교실
2가톨릭대학교 의과대학 소아과학교실
3연세대학교 의과대학 소아과학교실
4서울대학교 의과대학 소아과학교실
5순천향대학교 의과대학 소아과학교실
5순천향대학교 의과대학 소아과학교실
6인하대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Outbreaks of mumps continue to occur, even though the number of patients diagnosed of mumps has decreased considerably with the widespread use of vaccine. The accurate diagnosis of mumps is needed to understand the epidemiology of mumps and analyse the safety and effectiveness of vaccine. Therefore, we attempted to appraise the accuracy of provisional diagnosis of mumps in clinical practice by measuring mumps specific antibody.
Methods
: Thirty-six patients with presumptive diagnosis of mumps were enrolled from four university hospitals. Medical history including MMR vaccination was obtained, and anti-mumps IgM antibody test(ELISA. Denka Seiken Co., Ltd., Tokyo, Japan), complete blood counts and amylase were measured.
Results
: Among 36 patients presumptively diagnosed of mumps, anti-mumps IgM antibody was positive in 14 patients(38.8%), negative in 20(55.5%) and equivocal in 2(5.5%). In two patients who were not vaccinated against mumps, one had anti-mumps IgM antibody and the other did not. All four patients, vaccinated with MMR twice after their first birthday did not have anti-mumps IgM antibody. The sites of involved glands and the associated localized as well as systemic symptomatologies were not different between patients with anti-mumps antibody and those without. The proportion and degree of increment of serum amylase level were not different between the two groups.
Conclusion
: A significant number of patients with provisional diagnosis of mumps appear to be due to other causes. Amylase, commonly used in clinical practice, does not differentiate mumps from other illnesses involving the parotid glands. Mumps can be accurately diagnosed only by laboratory tests including anti-mumps antibody. The two-dose MMR vaccination program needs to be reinforced. |
| Key Words:
Mumps, Salivary gland swelling, Anti-mumps IgM antibody |
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