| The Relationship between Change of Cardiac Function and Systemic Oxygen Consumption according to the Dose of Dopamine in the Rabbit |
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Hee Ju Park1, Seok Ho Yoon1, Bong Seok Choi1, Jung Hwoi Cho1, Ku Tae Kim1, Sun Young K1, Sang Ook Nam1, Bok Luel Lee2 |
1Department of Pediatrics, College of Medicine, Pusan National University, Pusan, Korea
2Department of Phamacology, Pusan National University, Pusan, Korea |
| 가토에서 Dopamine의 투여 용량에 따른 심장 기능 변화와 전신 산소 소모량의 변화와의 관계 |
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박희주1, 윤석호1, 최봉석1, 최정화1, 김규태1, 김선영1, 남상욱1, 이복률2 |
1부산대학교 의과대학 소아과학교실
2부산대학교 약학대학 제약학과 |
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| Abstract |
Purpose
: We'd like to know the relationship between the changes of cardiac function and systemic O2 consumption according to the increasing dose of dopamine.
Methods
: Ten rabbits(from 2kg to 2.8kg) were used in this experiment. Anesthesia was induced with intraperitoneal pentobarbital sodium(35mg/kg) and tracheostomy was done. It was maintained by ventilation with a mixture of 1-3% halothane and 67-69% oxygen. Polyvinyl catheters were inserted into the femoral artery and vein and to check blood pressure and arterial blood gas analysis during the surgical procedure. Two other catheters were inserted into the internal carotid artery and external jugular vein and advanced into left ventricle and right atrium to check the pressure of each chamber, LV maximal dP/dt and to obtain blood samples of each chamber. Thoracotomy was done to expose aorta and coronary artery to check the cardiac output and coronary blood flow. We injected dopamine every 10 minutes according to the scheduled dose through external jugular vein and recorded heart rate, cardiac output, aortic pressure, maximal dP/dt, coronary blood flow by computer. Systemic O2 consumption was calculated by Fick method
Results
: The heart rate and mean aortic pressure increased slowly according to the dose of dopamine from 20μg/kg/min. The cardiac otuput the maximal dP/dt and coronary blood flow was not changed until 5μg/kg/min, but from 7.5μg/kg/min, it increased according to the dose of dopamine.
Conclusion
: Dopamine was a powerful inotrophic agent without increasing the systemic O2 consumption until 20μg/kg/min, but systemic O2 consumption increased markedly at more than 20 μg/kg/min of dopamine. |
| Key Words:
Dopamine, Heart rate, Mean aortic pressure, Cardiac output, Maximal dP/dt, Coronary blood flow, Systemic O2 consumption |
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