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A Case of Nonspecific Interstitial Pneumonia in a Child

Journal of the Korean Pediatric Society 2002;45(4):529-534.
Published online April 15, 2002.
A Case of Nonspecific Interstitial Pneumonia in a Child
Tae Wan Kim1, Dae-Hyun Lym1, Jung Hee Kim1, Byong Kwan Son1, Hye-Seung Han2, Young Kyu Shin3
1Department of Pediatrics, College of Medicine, Inha University, Incheon, Korea
2Department of Pathology, College of Medicine, Inha University, Incheon, Korea
3Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
소아 비특이성 간질성 폐렴 1례
김태완1, 임대현1, 김정희1, 손병관1, 한혜승2, 신영규3
1인하대학교 의과대학 소아과학교실
2인하대학교 의과대학 해부병리학교실
3고려대학교 의과대학 소아과학교실
Correspondence: 
Dae-Hyun Lym, Email: dhnlim@inha.ac.kr
Abstract
Department of Pediatrics†, College of Medicine, Korea University, Seoul, Korea Interstitial pneumonia is a heterogenous group of inflammatory and fibrosing lesions that manifest themselves as infiltrative lung disease. Of these, nonspecific interstitial pneumonia is characterized as a variable degree of interstitial inflammation with or without fibrosis and is distinguished from usual interstitial pneumonia and desquamative interstitial pneumonia, histologically. The influx of inflammatory cells and the responses of immune effector cells injury to the alveolar wall and these initial injuries results in alveolitis and fibrosis. Consequently, the gas exchange throughout the alveolar wall is impaired and the patients suffer from lung diseases of a restrictive pattern. The chief complaints represented are dyspnea and dry cough. We experienced a case of nonspecific interstitial pneumonia in a 10-year old girl. The patient had been healthy and had not been exposed to organic dusts or other toxic materials. The pathology of lung biopsy tissue showed that the alveoli were thickened by a mixture of chronic inflammatory cells and collagen type fibrosis. High resolution computed tomography(HRCT) found the patchy areas of ground-glass opacity with patchy consolidation and irregular reticular opacity, and diffuse distribution without zonal predominance. The forced vital capicity(FVC) was 31%, forced expiratory volume in one second (FEV1) 29% and FEV1/FVC 90%, so a restrictive pulmonary insufficiency was found.
Key Words: Nonspecific interstitial pneumonia(NSIP)


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