| A Case of Thyroxine Binding Globulin
Deficiency with Hypothyroidism |
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Dong-Chul Lee, Sun-Hee Lee, Jae-Hong Yu |
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Department of Pediatrics, College of Medicine, Chungnam National University, Daejon, Korea |
| 갑상선기능저하증을 동반한 티록신 결합글로불린 결핍증 1례 |
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이동철, 리선희, 유재홍 |
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충남대학교 의과대학 소아과학교실 |
Correspondence:
Jae-Hong Yu, Email: jhongyu@cuvic.cnu.ac.kr
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| Abstract |
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A child diagnosed with congenital hypothyroidism after newborn screening and follow up thyroid function test at 1 month of life in another general hospital demonstrated euthyroid state with thyroxine(T4) supplementation until the age of 22 months of life, when he was transferred to our hospital, where he was diagnosed as thyroxine binding globulin(TBG) deficiency with low T4 and TBG. Withdrawal of T4 at age of 26 months was associated with hyperthyrotropinemic hypothyroidism. This patient is a case of TBG deficiency associated with hypothyroidism, and in rare instances, TBG deficiency may lead to hypothyroidism requiring hormone supplementation. |
| Key Words:
Thyroxine binding globulin deficiency, Hypothyroidism |
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