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Prevalence and Risk Factors of Candida Sepsis in Neonatal Intensive Care Unit

Journal of the Korean Pediatric Society 2002;45(7):836-846.
Published online July 15, 2002.
Prevalence and Risk Factors of Candida Sepsis in Neonatal Intensive Care Unit
Ic Sun Choi1, Suk Hwan Lim2, Chang Yee Cho1, Young Youn Choi1, Tai Ju Hwang1
1Department of Pediatrics, Chonnam National University Medical School, Gwangju, Korea
2Department of Pediatrics, Mokpo Catholic Hospital, Mokpo, Korea
신생아 중환자실에서 캔디다 패혈증의발생 추이와 위험 인자
최익선1, 임석환2, 조창이1, 최영륜1, 황태주1
1전남대학교 의과대학 소아과학교실
2목포 가톨릭병원 소아과
Correspondence: 
Young Youn Choi, Email: yychoi@chonnam.ac.kr
Abstract
Purpose
: With the development of neonatal intensive care and the increased use of systemic antibiotics, candida sepsis has become one of the most important causes of neonatal morbidity and mortality. The purpose of this study was to investigate the prevalence rate and its associated risk factors.
Methods
: We retrospectively reviewed medical records of 28 cases with candida sepsis who were admitted in the neonatal intensive care unit(NICU) of Chonnam University Hospital from July 1995 to June 2001. Twenty-nine patients without candida sepsis were enrolled for the control group to verify the risk factors.
Results
: The overall incidence of candida sepsis was 0.61% for all NICU admissions and 3.68% for all very low birth weight infants with the gradual increase of the annual prevalance rate over time. The endotracheal intubation, percutaneous central vein catheter(PCVC), umbilical vein catheter, total parenteral nutrition, intralipid and dopamine were more applied than the control group (P<0.01 for all). The durations of mechanical ventilator care, central catheter appliance, nothing per os, and admission were also significantly longer than the control group(P<0.01 for all). Ampicillin/sulbactam, ceftazidime, amikacin, netilmicin, teicoplanin and imipenem/cilastatin were significantly more used than the control group(P<0.05). The durations of ampicillin/sulbactam, ceftazidime, netilmicin and imipenem/cilastatin administration were also proved to be significant as the risk factors(P<0.01).
Conclusion
: The average annual prevalence rate of candida sepsis in NICU for six years was 0.61% with gradual increasing tendency over time. The elimination of the above risk factors is important in decreasing neonatal morbidity and mortality associated with candida sepsis.
Key Words: Neonatal intensive case unit, Candida sepsis, Prevalence, Risk factors


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