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Renal Anomalies in Children with Turner Syndrome

Journal of the Korean Pediatric Society 2002;45(7):891-895.
Published online July 15, 2002.
Renal Anomalies in Children with Turner Syndrome
Ji Young Kim1, Sun Young Hong1, Young Mi Park2, Yong Hoon Park3, Woo Yeong Chung1
1Departments of Pediatrics , College of Medicine, Inje University, Busan, Korea
2Departments of Pediatrics, College of Medicine, Youngnam University, Taegu, Korea
3Departments of Pediatrics , College of Medicine, Inje University, Busan, Korea
Turner 증후군 환자에서 신기형에 관한 연구
김지영1, 홍선영1, 박영미2, 박용훈3, 정우영1
1인제대학교 의과대학 소아과학교실
2인제대학교 의과대학 진단방사선학교실
3영남대학교 의과대학 소아과학교실
Woo Yeong Chung, Email: chungwy@chollian.net
: The prevalence of renal anomalies in Turner syndrome(TS) has been reported to vary from 33% to 60%. The purpose of this study was to clarify the true incidence of renal malformations in Korean TS.
: We evaluated 33 patients with Turner syndrome diagnosed by karyotype in Inje University Busan Paik hospital and Youngnam University from January 1995. Intravenous pyelography(IVP) was performed on all patients; abdominal ultrasonography and 99mTc-DMSA renal scan were performed on some. Cytogenetic analysis was performed on all patients with peripheral blood lymphocytes.
: Of the total 33 patients, the karyotype showed 45, X in 18(54.5%) patients, mosaicism in 11(33.3%) patients and structural aberration in 4(12.2%) patients. The overall incidence of renal anomalies was 36.4%. The renal anomalies included four cases of horeshoe kidney, six cases of abnormal renal collecting system one case of single kidney and one case of malrotation. The incidence of renal anomalies in 45, X karotype(44.4%) showed a higher rate than that of mosaicism and structural aberration(26.7%), but there is no statistical significance.
: The incidence of renal anomalies in Korean TS reveals 36.4%. This rate is similar to other foreign TS studies. We recommend that renal ultrasonography or IVP for investigation of renal anomalies should be done as a screening procedure for the better quality of life in patients with TS.
Key Words: Turner syndrome, Renal anomalies, Karyotype, Korean

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