| Lifelong medical challenges and immunogenetics of turner syndrome |
Won Kyoung Cho 
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Department of Pediatrics, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea |
Correspondence:
Won Kyoung Cho, Tel: +82-031-249-8869, Fax: +82-031-249-8861, Email: wendy626@catholic.ac.kr
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Received: 13 March 2024 • Revised: 13 March 2024 • Accepted: 10 May 2024 |
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| Abstract |
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Turner syndrome (TS) is a female phenotypic condition characterized by one or more typical clinical features and the partial or complete absence of a second X chromosome as determined by karyotype analysis. TS, among the most common chromosomal abnormalities, has an estimated prevalence of approximately 1 in 2,500 live-born females, with ethnic and racial differences. TS encompasses a wide array of medical challenges, including cardiovascular, endocrine, autoimmune, and mental health issues, as well as a heightened cancer risk. The somatic stigmata of TS are thought to arise from haploinsufficiency of the X chromosomes. This review explores the lifelong medical challenges and immunogenetics of individuals with TS and aimed to investigate strategies for preventing and managing TS while considering the implications of immunogenetics. |
| Key Words:
Turner syndrome, Immunogenetics, X chromosome |
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