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Comparison of Two Rapid Antigen Detection Tests for Diagnosis of Group A Streptococcal Pharyngotonsillitis

Journal of the Korean Pediatric Society 2002;45(8):973-979.
Published online August 15, 2002.
Comparison of Two Rapid Antigen Detection Tests for Diagnosis of Group A Streptococcal Pharyngotonsillitis
Seung Kyu Song1, Mi Ae Hong1, Kyung Chang Oh1, Seung In Ahn1, Mi Hyon Tae1, Hye Jung Shin1, Jin Keun Chang1, Sung Ho Cha2
1Department of Pediatrics, Hanil General Hospital, Seoul, Korea
2Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea
A군 연쇄구균성 인두편도염 진단을 위한 두 종류 신속항원검사법의 비교
송승규1, 홍미애1, 오경창1, 안승인1, 태미현1, 신혜정1, 장진근1, 차성호2
1한일병원 소아과
2경희대학교 의과대학 소아과학교실
Correspondence: 
Jin Keun Chang, Email: atomjin@kepco.co.kr
Abstract
Purpose
: Recently, a number of rapid antigen detection tests have been available to diagnose group A streptococcal pharyngotonsillitis. The purpose of this study was to determine the sensitivity, specificity and consistency of the two rapid antigen detection tests.
Methods
: Among the patients who visited our clinic from November 2001 to February 2002, 61 patients who had clinical findings of pharyngeal erythema or edema, pharyngeal exudates and soft palatine petechiae were enrolled in our study. A total of 61 patients were tested with rapid antigen detection tests and throat culture. BD LINK2TM Strep A(Becton, Dickinson & Company, U.S.A.) and QuickVue In-LineTM(Quidel Corporation, U.S.A.) were selected for rapid antigen detection tests.
Results
: Of the 61 patients tested, 22 patients were confirmed as group A streptococcal pharyngotonsillitis by throat culture. The BD LINK2TM Strep A had a sensitivity of 81.8% and a specificity 89.7%. The positive and negative predictive values were 81.8% and 89.7%, respectively. The QuickVue In-LineTM had a sensitivity of 77.3% and a specificity of 100%. The positive and negative predictive values were 100% and 88.6%, respectively. The kappa values of BD LINK2TM Strep A and QuickVue In-LineTM were 0.72 and 0.81, respectively.
Conclusion
: In addition to high sensitivity, specificity and consistency, both kits are easy to use and simple to interpret, and therefore have the potential to be used with backup throat culture for diagnosis of acute pharyngotonsillitis.
Key Words: Group A β-hemolytic streptococcus, Acute pharyngotonsillitis, Rapid antigen detection tests


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