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A Case of Fetal Valproate Syndrome Associated with Both Elbow Joint Contractures

Journal of the Korean Pediatric Society 2002;45(10):1288-1292.
Published online October 15, 2002.
A Case of Fetal Valproate Syndrome Associated with Both Elbow Joint Contractures
Yun Chang Choi, Eun Young Kim, Kynug Rye Moon, Young Il Rho
Department of Pediatrics, College of Medicine, Chosun University, Gwangju, Korea
팔꿈치관절의 구축을 동반한 Fetal Valproate 증후군 1례
최윤창, 김은영, 문경래, 노영일
조선대학교 의과대학 소아과학교실
Correspondence: 
Young Il Rho, Email: ryoung@mail.chosun.ac.kr
Abstract
Fetal valproate syndrome has been described as a distinctive pattern of minor anomalies of the face and digits. This pattern has not been delineated completely but appears to involve brachycephaly with a high forehead, shallow orbit, ocular hypertelorism, small nose, small mouth, low set posteriorly rotated ears, long overlapping fingers and toes, and hyperconvex fingernail. Cleft palate and congenital heart disease have occasionally been described in babies exposed to valproate during embryogenesis. We report a neonate born from an epileptic mother receiving sodium valproate during pregnancy. This neonate presented with characteristic facial abnormalities, both elbow contractures, and overlapping of right first and second toe, forth and fifth toe, and left first and second toe. This case raises the possibility that these abnormal appearances might be caused by intrauterine valproate exposure.
Key Words: Fetal valproate syndrome, Elbow contracture


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