| Familial Adenomatous Polyposis Improved by
COX-2 Inhibitor in a Child |
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Ki Won Oh1, Se Young Kim1, Hwan Suk Lee1, Myung Hoon Lee2, Byung Ho Choe1 |
1Department of Pediatrics, Kyungpook National University, School of Medicine, Daegu, Korea
2Department of Pathology, Kyungpook National University, School of Medicine, Daegu, Korea |
| COX-2 억제제 투여 후 호전을 보인 가족성 선종성 용종증 1례 |
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오기원1, 김세영1, 이환석1, 이명훈2, 최병호1 |
1경북대학교 의과대학 소아과학교실
2경북대학교 의과대학 병리학교실 |
Correspondence:
Byung Ho Choe, Email: bhchoi@knu.ac.kr
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| Abstract |
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Familial adenomatous polyposis(FAP) is an autosomal dominant disease characterized by numerous adenomas in the colorectum. Patients with FAP are always at risk of malignant transformation, so that colectomy is unavoidable. NSAID, such as sulindac, and selective COX-2 inhibitor, such as celecoxib, have shown a positive effect on FAP by causing polyp regression in some patients. We report a case of FAP in a 9-year-old female whose polyposis regressed markedly after six months-treatment with celecoxib. |
| Key Words:
Familial adenomatous polyposis, NSAID, COX-2 inhibitor, Celecoxib |
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