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Alteration of Growth Factor Expression after Acute Ischemic Renal Injury

Journal of the Korean Pediatric Society 2003;46(7):687-694.
Published online July 15, 2003.
Alteration of Growth Factor Expression after Acute Ischemic Renal Injury
Yang Sim Koe1, Soo Yeon Lee1, Won Kim2, Soo Chul Cho1, Pyoung Han Hwang1, Jung Soo Kim1, Dae-Yeol Lee1
1Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea
2Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea
급성 허혈성 신손상 후 여러 성장인자 발현의 변화
고양심1, 이수연1, 김원2, 조수철1, 황평한1, 김정수1, 이대열1
1전북대학교 의과대학 소아과학교실
2전북대학교 의과대학 내과학교실
Dae-Yeol Lee, Email: leedy@moak.chonbuk.ac.kr
: Regeneration and repair after ischemic renal injury appears to be modulated by circulating or locally produced growth factors. This study examined the changes of serum insulin like growth factor(IGF-I) and renal expression of IGF-I and II, vascular endothelial growth factor(VEGF), transforming growth factor-β(TGF-β), and connective tissue growth factor(CTGF) during the active regeneration period after acute ischemic injury.
: Sera and kidney tissue samples(whole kidney, cortex, outer medullae and inner medullae) were obtained before and after one, three, five and seven days of 40 minutes bilateral renal pedicle clamping. Acute renal failure was assessed by measuring the concentration of serum creatinine. Serum IGF-I level was measured by radioimmunoassay. The mRNA expression in kidney was measured by RT-PCR. The distribution of IGF-I and CTGF was detected by immunohistochemistry. Resuts : Serum IGF-I concentration after one day following acute ischemic renal injury was significantly decreased compared to preischemic value. The mRNA levels of IGF-I, IGF-II, TGF-β1 and VEGF in whole kidney were temporally decreased on day one of ischemic injury. IGF-I and IGF-II expressions in outer medullae were significantly decreased on day one after ischemic injury. TGF- β1, CTGF and VEGF expressions were markedly decreased in medullae after one day of ischemic injury compared to other kidney sections. IGF-I was markedly decreased in cortical tubules on day one of uremic rat. CTGF was markedly increased on tubule within three days of ischemic injury.
: These findings suggest that IGFs, TGF-β1 and CTGF may involve in the pathogenesis or the recovery from acute ischemic renal injury.
Key Words: Acute ischemic renal injury, Regeneration, Growth factor, IGF-I, IGF-II, TGF-β1, CTGF, VEGF

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