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Bronchoalveolar Cellularity and IL-8 Levels in Patients with Post-measles Wheezing

Journal of the Korean Pediatric Society 2003;46(8):763-768.
Published online August 15, 2003.
Bronchoalveolar Cellularity and IL-8 Levels in Patients with Post-measles Wheezing
Da Eun Jung1, Byeong Eui Kim1, Ju Young Chung1, Jeong Yeon Kim2, Sang Hyuk Ma3, Chang Keun Kim1
1Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea
2Department of Diagnostic Pathology, Inje University Sanggye Paik Hospital, Seoul, Korea
3Department of Pediatrics, Chang won Fatima Hospital, Chang won, Korea
홍역 후 천명환아의 기도내 세포양상 및 IL-8치
정다은1, 김병의1, 정주영1, 김정연2, 마상혁3, 김창근1
1인제대학교 의과대학 소아과학교실
2인제대학교 의과대학 진단병리과학교실
3창원 파티마병원 소아과
Correspondence: 
Chang Keun Kim, Email: kim.chang@mayo.edu
Abstract
Purpose
: This study was conducted to investigate the pulmonary cellular profiles and IL-8 levels in patients with post-measles wheezing.
Methods
: Twelve previously healthy infants with a minimum of three episodes of wheezing after measles pneumonia(Measles wheezing, median age, 1.3 years) were recruited by a retrospective examination of hospital records. They underwent bronchoalveolar lavage(BAL) with flexible bronchoscopy, and high-resolution computed tomography(HRCT) with a mean six(1-15) months interval. Comparisons were made with seven normal controls(Control, median age : 7.4 years). BAL cell counts and differentials were determined. IL-8 levels also were measured by ELISA.
Results
: The BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the Measles wheezing group(median 16.0%) compared to the control group(median 3.8 %)(P<0.01). IL-8 levels were markedly increased in the Measles wheezing group(mean켚D, 512.7?24.0 pg/mL) compared to the control group(41.7?7.7 pg/mL)(P<0.01). Furthermore, IL-8 levels correlated significantly(r=0.816, P=0.001) with neutrophil percentages in BAL fluids in the Measles wheezing group. Abnormal HRCT findings were mosaic perfusion, bronchiectasis, bronchial wall thickening, and decreased vascularity.
Conclusion
: These results suggest that pulmonary neutrophils and IL-8 may play an important role in the pathogenesis of the post-measles wheezing.
Key Words: Measles, Wheezing, Bronchoalveolar lavage, Neutrophils, IL-8


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