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Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease

Journal of the Korean Pediatric Society 2003;46(8):817-820.
Published online August 15, 2003.
Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease
Ji-Won Lee, Kyung-Yil Lee
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
가와사끼병에서 고용량 정맥용 면역글로불린 투여 후 생화학 지표들의 변화
이지원, 이경일
가톨릭대학교 의과대학 소아과학교실
Correspondence: 
Kyung-Yil Lee, Email: leekyungyil@yahoo.com
Abstract
Purpose
: Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD).
Methods
: Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times : before IVIG treatment and two hours, 24 hours and seven days after IVIG treatment. The samples were frozen at -20℃ before biochemical analysis.
Results
: A significant decrease in albumin concentration was found two hours h and 24 hours after IVIG treatment, but this recovered to the pretreatment level after seven days. Total cholesterol and triglyceride increased slightly after seven day. A significant decrease in HDL-cholesterol and C- reactive protein was seen two hours and 24 hours after IVIG treatment.
Conclusion
: High-dose IVIG affects immediate changes in protein profiles and HDL-cholesterol in KD. Changes in HDL-cholesterol induced by IVIG may be the result of changes in systemic protein metabolism.
Key Words: Intravenous immunoglobulin, Kawasaki disease, Proteins, Lipids, HDL-cholesterol


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