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A Case of Hemophagocytic Lymphohistiocytosis in a Child with Systemic Lupus Erythematosus

Journal of the Korean Pediatric Society 2003;46(10):1029-1031.
Published online October 15, 2003.
A Case of Hemophagocytic Lymphohistiocytosis in a Child with Systemic Lupus Erythematosus
Ja Young Hwang, Suk Man No, Jin Lee, Pil Sang Jang, Young Hoon Kim, Jin Tack Kim, Joon Sung Lee
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
전신성 홍반성 루푸스 환아에서 병발한혈구 탐식성 조직구 증식증 1례
황자영, 노석만, 이진, 장필상, 김영훈, 김진택, 이준성
가톨릭대학교 의과대학 소아과학교실
Correspondence: 
Jin Tack Kim, Email: jintackk@catholic.ac.kr
Abstract
Hemophagocytic lymphohistiocytosis is a reactive disorder characterized by a generalized non-malignant histiocytic proliferation with prominent hemophagocytosis by stimulated histiocytes in the bone marrow and reticuloendothelial systems resulting in pancytopenia and liver dysfunction. Several diseases including infection, malignancy and autoimmune disease are known to be causative disorders. This case demonstrated histiocytic hemophagocytosis in the bone marrow, resulting in pancytopenia during treatment of systemic lupus erythematosus and did not show any underlying disease.
Key Words: Hemophagocytic lymphohistiocytosis, Systemic lupus erythematosus


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