| Pathologic Change and Prognosis after Combination Therapy in
Advanced Neuroblastoma |
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Yeon Kyong Seo1, Yu Jin Jung1, Joon Sik Kim1, Heung Sik Kim1, Woo Hyun Park2, Soon Ok Choi2, Byung Yook Lee3, Kun Young Kwon3 |
1Department of Pediatrics, School of Medicine, Keimyung University, Daegu, Korea
2Department of Surgery, School of Medicine, Keimyung University, Daegu, Korea
3Departement of Pathology, School of Medicine, Keimyung University, Daegu, Korea |
| 소아 신경모세포종의 치료 후 조직소견의 변화와 예후와의 관계 |
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서연경1, 정유진1, 김준식1, 김흥식1, 박우현2, 최순옥2, 이병욱3, 권건영3 |
1계명대학교 의과대학 소아과학교실
2계명대학교 의과대학 소아외과학교실
3계명대학교 의과대학 해부병리과학교실 |
Correspondence:
Heung Sik Kim, Email: kimhs@dsmc.or.kr
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| Abstract |
Purpose
: Neuroblastoma is a malignant neoplasm which arises from primitive sympathetic neuroblasts, and occasionally can matured from a malignant neuroblastoma into a benign ganglioneuroma. It has the highest rate of spontaneous regression of any pediatric tumor. We performed a retrospective study of pathologic features after combination therapy in advanced neuroblastoma. Prognostic effects of the individual morphologic feature and prognostic groupings according to modified Shimada classification systems were analyzed.
Methods
: The treatment results for six patients with neuroblastoma seen at Keimyung University from Jan. 1991 to June 2000 were analyzed. Patients were treated with a combination of chemotherapy, radiation therapy, and surgery, and classified by two major prognostic criteria based on morphological features of neuroblastoma, such as modified Shimada classification and histologic grading.
Results
: Three cases were classified to a good histologic group; among them, two cases survived, but one case was lost in follow-up. There were three cases classified in a poor histologic group. All of these patients expired due to sepsis and hemorrhagic pancreatitis.
Conclusion
: Prognostic classification due to pathologic findings had significant value in evaluating the survival rate of neuroblastoma patients. |
| Key Words:
Neuroblastoma, Pathologic change, Prognosis |
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