Journal of the Korean Pediatric Society 2003;46(11):1107-1111.
Published online November 15, 2003.
Pathologic Change and Prognosis after Combination Therapy in Advanced Neuroblastoma
Yeon Kyong Seo1, Yu Jin Jung1, Joon Sik Kim1, Heung Sik Kim1, Woo Hyun Park2, Soon Ok Choi2, Byung Yook Lee3, Kun Young Kwon3
1Department of Pediatrics, School of Medicine, Keimyung University, Daegu, Korea
2Department of Surgery, School of Medicine, Keimyung University, Daegu, Korea
3Departement of Pathology, School of Medicine, Keimyung University, Daegu, Korea
소아 신경모세포종의 치료 후 조직소견의 변화와 예후와의 관계
서연경1, 정유진1, 김준식1, 김흥식1, 박우현2, 최순옥2, 이병욱3, 권건영3
1계명대학교 의과대학 소아과학교실
2계명대학교 의과대학 소아외과학교실
3계명대학교 의과대학 해부병리과학교실
Heung Sik Kim, Email:
: Neuroblastoma is a malignant neoplasm which arises from primitive sympathetic neuroblasts, and occasionally can matured from a malignant neuroblastoma into a benign ganglioneuroma. It has the highest rate of spontaneous regression of any pediatric tumor. We performed a retrospective study of pathologic features after combination therapy in advanced neuroblastoma. Prognostic effects of the individual morphologic feature and prognostic groupings according to modified Shimada classification systems were analyzed.
: The treatment results for six patients with neuroblastoma seen at Keimyung University from Jan. 1991 to June 2000 were analyzed. Patients were treated with a combination of chemotherapy, radiation therapy, and surgery, and classified by two major prognostic criteria based on morphological features of neuroblastoma, such as modified Shimada classification and histologic grading.
: Three cases were classified to a good histologic group; among them, two cases survived, but one case was lost in follow-up. There were three cases classified in a poor histologic group. All of these patients expired due to sepsis and hemorrhagic pancreatitis.
: Prognostic classification due to pathologic findings had significant value in evaluating the survival rate of neuroblastoma patients.
Key Words: Neuroblastoma, Pathologic change, Prognosis

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