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The Prevalence of Transfusion-Transmitted Virus Infection in Children

Korean Journal of Pediatrics 2004;47(2):183-186.
Published online February 15, 2004.
The Prevalence of Transfusion-Transmitted Virus Infection in Children
Ju Young Chung1, Tae Hee Han2, Eung Su Hwang3
1Department of Pediatrics, College of Medicine, Inje University, Seoul, Korea
2Department of Diagnostic Laboratory Medicine, College of Medicine, Inje University, Seoul, Korea
3Department of Microbiology, College of Medicine, Seoul National University, Seoul, Korea
소아의 Transfusion-Transmitted Virus 감염 유병률
정주영1, 한태희2, 황응수3
1인제대학교 의과대학 소아과학교실
2인제대학교 의과대학 진단검사의학교실
3서울대학교 의과대학 미생물학교실
Abstract
Purpose
: Transfusion-transmitted virus(TTV) is an newly described nonenveloped human virus, with a circular, negative stranded DNA genome. Although a high prevalence of TTV infection in the normal population has been demonstrated, there is a still possibility of association with hepatitis according to the genotype of TTV. The aim of this study is to investigate the prevalence of TTV infection in Korean children.
Methods
: Nested polymerase chain reaction(PCR) using priner sets generated from the noncoding region(NCR) of the viral genome was done in 105 children without liver disease, aged 0-15 years. We performed a second set of PCR using N22 primer in 88 children after the first set of PCR.
Results
: The TTV DNA was detectable in 36(34%) of 105 children without hepatitis by 5'NCR primer. The prevalence of TTV varied with age : <1 y, 16%(4/25); 1-3 y, 44%(15/31); 4-6 y, 31%(5/ 16); 7-9 y, 25%(3/12); 10-15 y, 14%(3/21). By using N22 primers, the prevalence of TTV DNA in children without hepatitis was 11.3%(11/88) : <1 y 8%(2/25); 1-3 y, 13.7%(4/29); 4-6 y, 6.2%(1/16); 7-9 y, 33.3%(2/6); 10-14 y, 8.2%(1/12).
Conclusion
: Our result showed a high prevalence of TTV infection, varying with age, in Korean children. Further evaluation of genotypes of TTV in patients with hepatitis and normal children is needed.
Key Words: Transfusion-Transmitted virus, Children


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