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Incidence and Risk Factors of Rehospitalization with Respiratory Syncytial Virus Infection in Premature Infants

Korean Journal of Pediatrics 2004;47(5):510-514.
Published online May 15, 2004.
Incidence and Risk Factors of Rehospitalization with Respiratory Syncytial Virus Infection in Premature Infants
Eun Ah Lee1, Jea Heon Jeong1, Seung Taek Yu1, Chang Woo Lee1, Hyang Suk Yoon1, Do Sim Park2, Yeon Kyun Oh3
1Department of Pediatrics, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan, Korea
2Department of Laboratory Medicine, Wonkwang University School of Medicine, Iksan, Korea
3Department of Pediatrics, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan, Korea
미숙아에서 RS 바이러스 감염으로 인한 재입원 빈도와 관련 인자
이은아1, 정재헌1, 유승택1, 이창우1, 윤향석1, 박도심2, 오연균3
1원광대학교 의과대학 소아과학교실
2원광대학교 의과대학 진단검사의학교실
3원광대학교 의과대학 소아과학교실, 원광의과학연구소
Correspondence: 
Yeon Kyun Oh, Email: oyk5412@wonkwang.ac.krv
Abstract
Purpose
: We performed this study to evaluate the risk of rehospitalization for respiratory syncytial virus(RSV) infection among premature infants discharged from a neonatal intensive care unit(NICU).
Methods
: We performed a retrospective study for rehospitalization for RSV infection and risk factors among premature infants who were admitted to NICU and discharged between May 2001 and April 2003 in Wonkwang University Hospital. RSV detection was utilized by direct fluorescent antibody tests in nasopharyngeal aspirates. We also reviewed various risk factors including gestational age, birth weight, sex, ventilatory care, surfactant administration, chronic lung disease(CLD), siblings in school or kindergarten age, and month of discharge.
Results
: The rehospitalization rate for RSV infection was 6.6%(26/381) in premature infants and 22.2%(4/18) in premature infants with CLD. The most common season of rehospitalization for RSV infection was between November to January, this was 69.2%(18/26) in premature infants, the same as children : 61.2%(93/152). The risk factors for RSV rehospitalization among premature infants were CLD, siblings in school or kindergarten age and discharge between October to December from NICU.
Conclusion
: The risk for RSV rehospitalization among premature infants from NICU was low. Preterm infants subject to risk factors of CLD, siblings in school or kindergarten age, and discharge between October to December from NICU, were most likely to require hospitalization for RSV disease. In conclusion : Prophylaxis for RSV infection should be considered one month before discharge from NICU in the RSV season between October and December.
Key Words: Respiratory Syncytial virus, Rehospitalization, Premature


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