| Prevention of Chronic Lung Disease with Early Dexamethasone Treatment in less than 32 Weeks Premature : Randomized Controlled Study |
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So Yun Shim, Su Jin Cho, Eun Ae Park |
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Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea |
| 32주 미만 미숙아에서 조기 Dexamethasone 치료의 만성 폐질환 예방 효과 |
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심소연, 조수진, 박은애 |
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이화여자대학교 의과대학 소아과학교실 |
Correspondence:
Eun Ae Park, Email: pea8639@ewha.ac.kr
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| Abstract |
Purpose
: The optimal timing and the consequences of dexamethasone therapy in chronic lung disease remain unknown. The purpose of this study was to determine whether early dexamethasone therapy would reduce the incidence of chronic lung disease and to determine the adverse effects and complications of prematurity associated with such therapy.
Methods
: Twenty neonates with hyaline membrane disease(dexamethasone n=10, placebo n=10) of less than 32 weeks of gestation at Ewha Womens University Mokdong Hospital were enrolled. Infants were randomized to receive either early dexamethasone or placebo within 12 hours after birth for three days at 10 day intervals until postconceptional age was 36 weeks.
Results
: There were no significant differences in the incidence of chronic lung disease, duration of the ventilator therapy, O2 therapy and the duration of admission in the NICU. Retinopathy of prematurity and periventricular leukomalacia were more common in the dexamethasone-treated group(P< 0.05). There were no different in other complications between two groups.
Conclusion
: This study suggests that dexamethasone treatment in extreme low birth weight premature infants may be discouraged. And the duration of treatment and total dosage of dexamethasone should be reevaluated. |
| Key Words:
Early dexamethasone treatment, Premature, Chronic lung disease, Respiratory distress syndrome |
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