| Effects of the Chronic Use of Anticonvulsants on Bone Mineral Density in Children with Epilepsy |
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Hyun Hee Oh1, You Cheol Jang1, Byung Ho Choe1, Il Hyung Park2, Soon Hak Kwon1 |
1Departments of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea
2Departments of Orthopedics, School of Medicine, Kyungpook National University, Daegu, Korea |
| 소아 간질 환자에서 항경련제의 장기 투여가 골밀도에 미치는 영향 |
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오현희1, 장유철1, 최병호1, 박일형2, 권순학1 |
1경북대학교 의과대학 소아과학교실
2경북대학교 의과대학 정형외과학교실 |
Correspondence:
Soon Hak Kwon, Email: shkwon@knu.ac.kr
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| Abstract |
Purpose
: Chronic administration of anticonvulsants for children with epilepsy may cause multiple abnormalities in bone metabolism. The aim of this study was to evaluate the effects of anticonvulsants on bone mineral density(BMD) in children with epilepsy.
Methods
: Seventy patients with epilepsy were enrolled in this study. All subjects had taken anticonvulsants for at least 1 year or more. Subjects were classified into three groups according to age(5-7 yrs, 8-11 yrs, >12 yrs). BMD was measured by Dual-energy X-ray Absorptiometry(DXA) on the lumbar spine and whole body. Statistical analysis for BMD of anticonvulsants-treated subjects were compared to results with the published data.
Results
: BMD was significantly decreased in the anticonvulsants-treated group as compared with the control group of all age groups(P<0.05). But BMD among groups according to anticonvulsants was not significantly different(P>0.05).
Conclusion
: Because chronic administration of anticonvulsants for growing children leads to a decrease in BMD, early detection and management of abnormal BMD is important in monitoring of children with epilepsy. |
| Key Words:
Anticonvulsants, Bone density, Child |
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