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The Levels of Zinc and Neuron-specific Enolase in Febrile Convulsion

Korean Journal of Pediatrics 2004;47(10):1087-1092.
Published online October 15, 2004.
The Levels of Zinc and Neuron-specific Enolase in Febrile Convulsion
Hong Sang Cho1, Jun Hun Shin1, Ji Yeoung Seo1, Cho Ae Lee1, Se Hyun Kim2, Kyu Young Chae1
1Department of Pediatrics, College of Medicine, Pochon CHA University, Seongnam, Korea
2Department of Preventive Medicine, College of Medicine, Pochon CHA University, Seongnam, Korea
열성경련 환아에서 아연과 Neuron-specific Enolase의 농도에 관한 연구
조홍상1, 신준헌1, 서지영1, 이초애1, 김세현2, 채규영1
1포천중문의과대학교 소아과학교실
2포천중문의과대학교 예방의학교실
Correspondence: 
Kyu Young Chae, Email: barnabas@cha.ac.kr
Abstract
Purpose
: To determine the role of zinc in febrile convulsion and to evaluate whether febrile convulsion causes neuronal damage, serum and cerebrospinal fluid(CSF), zinc and CSF neuron-specific enolase(NSE) levels were measured in patients with febrile convulsion, epilepsy and aseptic meningitis.
Methods
: Three groups were formed as follows : group I : 53 children with febrile convulsion; group II : 34 children with epilepsy; and group III, 40 children with aseptic meningitis. Serum and CSF zinc and CSF NSE levels were measured in each groups.
Results
: The serum zinc levels of groups I, II and III had a mean of 74.71?8.26 g/dL, 104.35?1.43 g/dL and 87.03?4.47 g/dL, respectively, and the values of group I were significantly lower than those of the other two groups. The CSF zinc levels of groups I, II and III were found to have a mean 27.72?7.93 g/dL, 44.73?6.72 g/dL and 54.44?8.43 g/dL, respectively. In group I, the CSF zinc levels were significantly lower than those of other two groups. The CSF NSE levels of groups I, II and III had a mean of 11.61?.96 ng/mL, 16.51?.46 ng/mL and 14.60?.02 ng/mL respectively and the values of group I were significantly lower than those of others.
Conclusion
: We confirmed that low zinc levels in serum and CSF are participants in the pathogenesis of febrile convulsion, but we could not find out the evidence of neurologic damage in patients with febrile convulsion using NSE levels in CSF.
Key Words: Febrile convulsion, Zinc, Neuron-specific enolase


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