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A Case of Fulminant Hepatitis from Hepatitis A in a Child

Korean Journal of Pediatrics 2004;47(10):1106-1109.
Published online October 15, 2004.
A Case of Fulminant Hepatitis from Hepatitis A in a Child
Young Min Kim1, Jae Sun Kim1, Sun Hwan Bae2, Dong Hoon Kim3
1Department of Pediatrics, College of Medicine, Eulji University, Seoul, Korea
2Department of Pediatrics, College of Medicine, Eulji University, Seoul, Korea
3Department of Pathology, College of Medicine, Eulji University, Seoul, Korea
소아에서 전격성 간염으로 발현된 A형 간염 1례
김영민1, 김재선1, 배선환2, 김동훈3
1을지의과대학 소아과학교실
2 건국대학교 의과대학 소아과학교실
3을지의과대학 해부병리학교실
Correspondence: 
Sun Hwan Bae, Email: baedori@hanafos.com
Abstract
Fulminant hepatitis from hepatitis A in children is rare and has a low survival rate. We report a case of fulminant hepatitis from hepatitis A in a 12-year-old girl. The patient was admitted because of a three day history of fever, epigastric pain and vomiting. On her second hospital day, she had insomnia, anxiety, dysthesia, continuous fever, vomiting and nausea. In laboratory findings, decreased white blood cell and platelet count, markedly elevated serum aminotransferase levels, elevated serum bilirubin levels, prolonged prothrombin time and partial thromboplastin time were seen. Factor VIII appeared normal range. The histopathologic findings were necrosis in hepatic lobules, periportal necrosis, portal lymphocytic infiltration and fibrous portal expansion. We treated the patient with supportive care. After treatment, clinical manifestations and laboratory findings were improved.
Key Words: Hepatitis A, Fulminant hepatitis, Child


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