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Clinical Utilities of Serum Ferritin as a Marker of Disease Activity and Prognostic Factor in Childhood Tumors

Korean Journal of Pediatrics 2004;47(12):1319-1324.
Published online December 15, 2004.
Clinical Utilities of Serum Ferritin as a Marker of Disease Activity and Prognostic Factor in Childhood Tumors
Eun Seok Roh1, Jung Hyun Lee1, Yu Ra Hong1, Jae Sun Park1, Jong Shin Kim2
1Department of Pediatrics, College of Medicine, Kosin University, Busan, Korea
2Kimhae Alliance Pediatric Clinic, Busan, Korea
소아 종양 환자에서 질병의 활성도에 따른 혈청 Ferritin 치의 유용성
노은석1, 이정현1, 홍유라1, 박재선1, 김종신2
1고신대학교 의과대학 소아과학교실
Jae Sun Park, Email: pjs@ns.kosinmed.or.kr
: In order to assess the usefulness of serum ferritin as a marker of disease activity and prognostic factor in pediatric malignancy, serum ferritin levels were measured.
: Peripheral blood samplings for ferritin level were made at presentation, in remission following therapy, and in relapse in 95 children with malignancy admitted to the Department of Pediatrics, Kosin University Gospel Hospital between January, 1986 and August, 1995. The patients were comprised of 35 acute lymphoblastic leukemia(ALL), 17 acute myelogenous leukemia(AML), 20 non- Hodgkin's lymphoma(NHL) and 23 neuroblastoma(NB).
: The mean values of serum ferritin at presentation were 465.3?3.9 ng/mL in ALL, 468.9?9.4 ng/mL in AML, 274.1?9.2 ng/mL in NHL and 337.3?4.4 ng/mL in NB. Those values were increased significantly compared to the mean of 20 control children(69.5?2.9 ng/mL). The mean values of serum ferritin concentration in remission stage(first, second, and third remission) tend to be lower compared to those in the active stage(at presentation, first relapse and second relapse). But these differences reached a statistical significance only in patients with ALL when the mean values of the active stage were compared to those checked in the remission stage over 12 months(P= 0.0002). Comparison of overall survival according to initial serum ferritin levels(below and above 200 ng/mL) did not show any significant difference in ALL, AML and NHL. However, there was a borderline relationship in NB(relative risk 3.12, P=0.06).
: The study showed that normalization of serum ferritin levels were found in ALL who had continuous, complete remission for more than 12 months. And patients with lower serum ferritin levels were not associated with better survival except in patients with NB in which the lower ferritin group showed borderline significance.
Key Words: Ferritin, Prognosis, Leukemia, Lymphoma, Neuroblastoma, Children

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